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Developmental Cortical Physiology Laboratory

Evelyn Lambe, Ph.D.

Canada Research Chair in
Developmental Cortical Physiology

Associate Professor
Department of Physiology
University of Toronto

1 King's College Circle
Toronto ON
Canada M5S 1A8

evelyn.lambe@utoronto.ca

Research Overview

We probe developmental and disease-related changes in the physiology and pharmacology of prefrontal cortex and other brain regions important for cognition and mood.

Recruiting: Enthusiastic and highly motivated scientists
Do you have expertise in electrophysiology, multiphoton imaging, optogenetics, molecular/protein techniques, and/or mouse behaviour?
*** Please apply with c.v. describing your research experience in detail to evelyn.lambe (at) utoronto.ca

Researchers

In order of appearance...

Sridevi Venkatesan, Graduate student Sridevi

Kath Intson, Graduate student Kath

Saige Power, Undergraduate researcher Saige

Janice McNabb, Research Assistant Janice

Mary Binko, Graduate student

Dr. Daniel Sparks, Postdoctoral Fellow Dan Sparks

Alzheimer's Society of Canada Research Program Postdoctoral Fellowship 2017

David Oliver, Undergraduate researcher

NSERC summer student 2017

Lab Alumni

Duong "Izzy" Chu, Research Assistant

Medical student at Queens University

Izzy Chu

Dr. Derya Sargin, Postdoctoral Fellow

New position at the University of Calgary

Dr. Michael Tian, Ph.D. student

Now at Millenium

Mike Tian

Dr. Éliane Proulx, Ph.D. student

Postdoctoral Fellow, Max Planck Institute, Germany

Eliane

Lily Kang, Undergraduate Researcher then Research Assistant

Medical student, Monash University, Australia

Kristina Perit, M.Sc. student

Science writer

Dr. Nathalie Goodfellow, Ph.D. student

Medical Science Liaison at Roche Pharmaceuticals

Matt Piva, UBC undergraduate and NSERC summer student

Now an NSERC-funded Ph.D. student in Neuroscience at Yale University.

Dr. Craig Bailey, Postdoctoral Research Associate

Now a tenure-track Assistant Professor at the Ontario Veterinary College & University of Guelph.

Ryan O'Reilly, McMaster undergraduate and Summer Research Assistant

Nyresa Alves, M.Sc. student

Now in the Faculty of Dentistry at the University of Toronto.

nyresa

Sameera Kassam, Research Assistant

Patrick Herman, Undergraduate Researcher and Research Assistant

Recent visual abstracts

Sargin visual abstract

Sargin et al. eLife, 2016

Tian visual abstract

Tian et al., eNeuro, 2016

Lambe Lab Publications

D. Sargin, D. Oliver, E.K. Lambe (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels. eLife Nov 22;5. pii: e21416. doi: 10.7554/eLife.21416. abstract

M.K. Tian, E.F. Schmidt, E.K. Lambe (2016) Serotonergic Suppression of Mouse Prefrontal Circuits Implicated in Task Attention. eNeuro 2016 Nov 8;3(5). pii: ENEURO.0269-16.2016. abstract

E. Proulx, P. Fraser, J. McLaurin, E.K. Lambe (2015) Impaired cholinergic excitation of prefrontal attention circuitry in the TgCRND8 model of Alzheimer's Disease. Journal of Neuroscience 35: 12779-12791.    abstract

L. Kang, M.K. Tian, C.D. Bailey, E.K. Lambe (2015) Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors. Frontiers in Cellular Neuroscience 9: 398.   abstract

M. Soiza-Reilly, N.M. Goodfellow, E.K. Lambe (2015) Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology 89:185-92.   abstract

T.J. Rebello, Q. Yu, N.M. Goodfellow, M.K. Caffrey Cagliostro, A. Teissier, E. Morelli, E.Y. Demireva, A. Chemiakine, G.B. Rosoklija, A.J. Dwork, E.K. Lambe, J.A. Gingrich, M.S. Ansorge (2014) Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function. Journal of Neuroscience   34:12379-93.   abstract

M.K. Tian, C.D.C. Bailey, E.K. Lambe (2014) Cholinergic excitation in mouse primary vs. associative cortex: region-specific magnitude and receptor balance. European Journal of Neuroscience 40(4):2608-18.   abstract

N.M. Goodfellow*, D. Sargin*, M.S. Ansorge, J.A. Gingrich, E.K. Lambe (2014) Mice with compromised 5-HTT function lack phosphotyrosine-mediated inhibitory control over prefrontal 5-HT responses. Journal of Neuroscience 34:6107-11. abstract      (See below for Supplemental Figure)

E. Proulx, D. Suri, S.P. Heximer, V.A. Vaidya, E.K. Lambe (2014) Early stress prevents the potentiation of muscarinic excitation by calcium release in adult prefrontal cortex. Biological Psychiatry 76(4):315-23. abstract

E. Proulx, M. Piva, M.K. Tian, C.D.C. Bailey, E.K. Lambe (2014) Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex. Cellular and Molecular Life Sciences 71(7):1225-44 abstract

C.D.C. Bailey, M.K. Tian, L. Kang, R. O'Reilly, E.K. Lambe (2014) Chrna5 genotype determines the long-lasting effects of developmental in vivo nicotine exposure on prefrontal attention circuitry. Neuropharmacology 77:145-55 abstract

N.M. Goodfellow, C.D.C. Bailey, E.K. Lambe (2012) The native serotonin 5-HT5A receptor: Electrophysiological characterization in rodent cortex and 5-HT1A-mediated compensatory plasticity in the knock-out mouse. Journal of Neuroscience 32(17): 5804-9.   abstract

C.D.C. Bailey, N. Alves, R. Nashmi, M. De Biasi, E.K. Lambe (2012) Nicotinic α5 subunits drive developmental changes in the activation and morphology of prefrontal cortex layer VI neurons. Biological Psychiatry 71(2):120-8. abstract

M.K. Tian, C.D.C. Bailey, M. De Biasi, M.R. Picciotto, E.K. Lambe (2011) Plasticity of prefrontal attention circuitry: Upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits. Journal of Neuroscience 31: 16458-63. abstract

E.K. Lambe, S.G. Fillman, M.J. Webster, C.S. Weickert (2011) Serotonin receptor expression in human prefrontal cortex: Balancing excitation and inhibition across postnatal development. PLoS One 6: (e22799) 1-10. abstract

G.M. Pitcher, L.V. Kalia, D. Ng, N.M. Goodfellow, K.T. Yee, E.K. Lambe, M.W. Salter (2011) Schizophrenia susceptibility pathway neuregulin1-ErbB4 suppresses the Src kinase upregulation of NMDA receptors in the induction of lasting synaptic potentiation. Nature Medicine 17: 470-8. abstract

M. Benekareddy*, N.M. Goodfellow*, E.K. Lambe**, V.A. Vaidya** (2010) Enhanced function of prefrontal serotonin 5-HT2A receptors in a rat model of psychiatric vulnerability. Journal of Neuroscience 30:12138-12150.
* equally contributing first authors; ** equally contributing senior and corresponding authors abstract

C.D.C. Bailey, M. De Biasi, P. Fletcher, E.K. Lambe (2010) The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. Journal of Neuroscience 30:9241-9252. abstract

E. Proulx, E.J. Young, L.R. Osborne, E.K. Lambe (2010) Enhanced prefrontal serotonin 5-HT_1A currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. Journal of Neurodevelopmental Disorders 2: 99-108. abstract

N.Alves, C.D.C. Bailey, R. Nashmi, E.K. Lambe (2010) Developmental sex differences in nicotinic currents of prefrontal layer VI neurons in mice and rats. PLoS One 5: e9261. abstract

N.M. Goodfellow, M. Benekareddy, V.A. Vaidya, E.K. Lambe (2009) Layer II/III of the prefrontal cortex: Inhibition by the serotonin 5-HT_1A receptor in development and stress. Journal of Neuroscience 29: 10094-103. abstract

S.M. Kassam*, P.M. Herman*, N.M. Goodfellow, N.C. Alves, E.K. Lambe (2008) Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptors. Journal of Neuroscience 28: 8756-64. * equally contributing first authors abstract

Funding

Scottish Rite Charitable Foundation of Canada

Supplemental Figure for Goodfellow, Sargin et al, 2014:

supp fig