Selected Publications

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·         Amini-Nik S, Glancy D, Boimer C, Whetstone H, Keller C, Alman BA. Pax7 Expressing Cells Contribute to Dermal Wound Repair; Regulating Scar Size Through a β-Catenin Mediated Process. Stem Cells. 2011 Jul 7. doi: 10.1002/stem.688.

·         Alman B, Kelley S, Nam D. Heal Thyself: Using endogenous regeneration to repair bone. Tissue Eng Part B Rev. 2011 Jun 17.

·         Bielefeld KA, Amini-Nik S, Whetstone H, Poon R, Youn A, Wang J, Alman BA. Fibronectin and {beta}-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. J Biol Chem. 2011 Jun 7.

·         Hong H, Nadesan P, Poon R, Alman BA. Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour). Br J Cancer. 2011 Apr 26;104(9):1452-8. Epub 2011 Apr 5.

·         Rockel JS, Alman BA. Don't hedge your bets: hedgehog signaling as a central mediator of endochondral bone development and cartilage diseases. J Orthop Res. 2011 Jun;29(6):810-5. doi: 10.1002/jor.21372. Epub 2011 Feb 9.

·         Amini-Nik S, Kraemer D, Cowan ML, Gunaratne K, Nadesan P, Alman BA, Miller RJ. Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgery. PLoS One. 2010 Sep 28;5(9). pii: e13053.

·         Wu C, Amini-Nik S, Nadesan P, Stanford WL, Alman BA. Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells. Cancer Res. 2010 Oct 1;70(19):7690-8. Epub 2010 Sep 14.

·         Bovée JV, Hogendoorn PC, Wunder JS, Alman BA. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer. 2010 Jul;10(7):481-8. Epub 2010 Jun 10. Review.

·         Offiah A, Alman B, Cornier AS, Giampietro PF, Tassy O, Wade A, Turnpenny PD; ICVAS (International Consortium for Vertebral Anomalies and Scoliosis). Pilot assessment of a radiologic classification system for segmentation defects of the vertebrae. Am J Med Genet A. 2010 Jun;152A(6):1357-71.


·         Lipa JE, Qiu W, Huang N, Alman BA, Pang CY. Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction.

Plast Reconstr Surg. 2010 Feb;125(2):437-45.

·         Ho L, Alman B. Protecting the hedgerow: p53 and hedgehog pathway interactions. Cell Cycle. 2010 Feb 1;9(3):506-11. Review.

·         Lin AC, Seeto BL, Bartoszko JM, Khoury MA, Whetstone H, Ho L, Hsu C, Ali AS, Alman BA. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med. 2009 Nov 15

·         Ho L, Stojanovski A, Whetstone H, Wei QX, Mau E, Wunder JS,Alman BA. Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. Cancer Cell. 2009 Aug 4;16(2):126-36.

·         Chen Y, Alman BA. Wnt pathway, an essential role in bone regeneration. J Cell Biochem 2009, 106:353-362 (Review)

·         Gurung A, Uddin F, Hill RP, Ferguson PC, Alman BA. Beta-Catenin is a mediator of the response of fibroblasts to irradiation. Am J Pathol. 2009, 174: 248-255

·         Alman BA, Wunder JS. Parathyroid hormone-related protein regulates glioma-associated oncogene transcriptional activation: lessons learned from bone development and cartilage neoplasia. Ann N Y Acad Sci 2008, 1144: 36-41 (Review)

·         Lavoie JF, Biernaskie JA, Chen Y, Bagli D, Alman BA, Kaplan DR, Miller FD. Skin-derived Precursors Differentiate into Skeletogenic Cell Types and Contribute
to Bone Repair. Stem Cells Dev 2008 Oct 3. [Epub ahead of print]

·         Silkstone D, Hong H, Alman BA. Beta-Catenin in the race to fracture repair: in it to Wnt. Nat Clin Pract Rheumatol 2008, 4: 413-419 (Review)

·         Wu C, Alman BA. Side population cells in human cancers. Cancer Lett 2008, 268: 1-9 (Review)

·         Alman BA. Skeletal dysplasias and the growth plate. Clin Genet 2008, 73: 24-30 (Review)

  • Wu C*, Wei Q*, Utomo V, Nadesan P, Whetstone H, Kandel R, Wunder JS, Alman BA. Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. Cancer Res 2007, 67: 8216-8222

·         Tjandra SS, Hsu C, Goh I, Gurung A, Poon R, Nadesan P, Alman BA. IFN-beta signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors. Cancer Res 2007, 67: 7124-7131

·         Chen Y, Whetstone HC, Lin AC, Nadessan P, Wei Q,  Poon R, Alman BA. Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med 2007, 4: 1216-1229

·         Wunder JS, Nielsen TO, Maki RG, O'sullivan B, Alman BA. Opportunities for improving the therapeutic ratio for patients with sarcoma. Lancet Oncol 2007, 8: 513-524 (Review)

·         Donaldson S, Stephens D, Howard A, Alman BA, Narayanan U, Wright JG. Surgical decision making in adolescent idiopathic scoliosis. Spine 2007, 32: 1526-1532

·         Baliko F, Bright T, Poon R, Cohen B, Egan SE, Alman BA. Inhibition of notch signaling induces neural differentiation in ewing sarcoma. Am J Pathol 2007, 170: 1686-1694

·         Boutis K, Willan AR, Babyn P, Narayanan UG, Alman BA, Schuh S. A randomized, controlled trial of a removable brace versus casting in children with low-risk ankle fractures. Pediatrics 2007, 119: e1256-1263

·         Li CF, MacDonald JR, Wei RY, Ray J, Lau K, Kandel C, Koffman R, Bell S, Scherer SW, Alman BA. Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. BMC Genomics 2007, 8: 92

·         Turnpenny PD, Alman BA, Cornier AS, Giampietro PF, Offiah A, Tassy O, Pourquie O, Kusumi K, Dunwoodie S.Abnormal vertebral segmentation and the notch signaling pathway in man. Dev Dyn 2007, 236: 1456-1474

·         Alman BA, Horton WA. Developmental biology in orthopaedics. Summary of the 2006 AAOS research symposium.
J Bone Joint Surg 2007, 89A: 668-671

·         Mau E, Whetstone HC, Yu C, Hopyan S, Wunder JS, Alman BA. PTHrP regulates growth plate chondrocytes differentiation and proliferation in a Gli3 dependent manner utilizing Hh ligand dependent and independent mechanism. Dev Biol 2007, 305: 28-39

·         Chen Y, Whetstone HC, Youn A, Nadessan P, Chow E, Lin AC, Alman BA. Beta-catenin signaling pathway is crucial for bone morphogenetic protein-2 to induce new bone formation. J Biol Chem 2007, 282: 526-533

·         Cheon SS, Wei Q, Gurung A, Youn A, Bright T, Poon R, Whetstone H, Guha A, Alman BA. Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J 2006, 20: 692-701

·         Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS.Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. Am J Pathol 2006, 168: 321-330

·         Alman BA. Duchenne muscular dystrophy and steroids: pharmacologic treatment in the absence of effective gene therapy. J Pediatr Orthop 2005, 25: 554-5546 (Review)

·         Hopyan S, Nadesan P, Yu C, Wunder J, Alman BA. Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. J Pathol 2005, 206: 143-150

·         Fen Li C, Kandel C, Baliko F, Nadesan P, Brunner N, Alman BA. Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor). Oncogene 2005, 24: 1615-1624

·         Cheon S, Poon R, Yu C, Khoury M, Shenker R, Fish J, Alman BA. Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. Lab Invest 2005, 85: 416-425

·         Kong Y, Poon R, Nadesan P, Di Muccio T, Fodde R, Khokha R, Alman BA. Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. Cancer Res 2004, 64: 5795-5803

·         Alman BA, Raza SN, Biggar WD. Steroid treatment and the development of scoliosis in males with duchenne muscular dystrophy. J Bone Joint Surg 2004, 86A: 519-524

·         Denys H, Jadidizadeh A, Amini Nik S, Van Dam K, Aerts S, Alman BA, Cassiman JJ, Tejpar S. Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. Oncogene 2004, 23: 654-664

·         Cheon SS, Nadesan P, Poon R, Alman BA. Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. Exp Cell Res 2004, 293: 267-274

·         Yu C, Le AT, Yeger H, Perbal B, Alman BA. NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol 2003, 201: 609-615

·         Tolg C, Poon R, Fodde R, Turley EA, Alman BA. Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Oncogene 2003, 22: 6873-6882

·         Plasschaert F, Craig C, Bell R, Cole WG, Wunder JS, Alman BA. Eosinophilic granuloma, a different behavior in children than in adults. J Bone Joint Surg 2002, 84B: 870-872

·         Alman BA. A classification for genetic disorders of interest to orthopaedists. Clin Orthop 2002, 401: 17-26

·         Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, Alman BA. Beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci USA 2002, 99: 6973-6978

·         Hopyan S, Gokgoz N, Poon R, Gensure RC, Yu C, Cole WG, Bell RS, Juppner H, Andrulis IL, Wunder JS, Alman BA. A mutant PTH/PTHrP type I receptor in enchondromatosis. Nat Genet 2002, 30: 303-310

·         Meng X, Poon R, Zhang X, Cheah A, Ding Q, Hui CC, Alman BA. Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem 2001, 276: 40113-40119

  • Boutis K, Komar L, Jaramillo D, Babyn P, Alman BA, Snyder B, Mandl KD, Schuh S. Sensitivity of a clinical examination to predict need for radiography in children with ankle injuries: a prospective study. Lancet. 2001,358: 2118-2121

·         Tejpar S, Li C, Yu C, Poon R, Denys H, Sciot R, Van Cutsem E, Cassiman JJ, Alman BA. Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour). Br J Cancer 2001, 85: 98-101

·         Li C, Nguyen Q, Cole WG, Alman BA. Potential treatment for clubfeet based on growth factor blockade. J Pediatr Orthop 2001, 21: 372-377

·         Poon R, Smits R, Li C, Jagmohan-Changur S, Kong M, Cheon S, Yu C, Fodde R, Alman BA. Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). Oncogene 2001, 20: 451-460

·         Tejpar S, Nollet F, Li C, Wunder JS, Michils G, dal Cin P, Van Cutsem E, Bapat B, van Roy F, Cassiman JJ, Alman BA. Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). Oncogene 1999, 18: 6615-6620

·         Hopyan S, Gokgoz N, Bell RS, Andrulis IL, Alman BA, Wunder JS. Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. J Orthop Res 1999, 17: 633-638