Mitesh V. Badiwala, MD - Curriculum Vitae

Curriculum Vitae<= o:p>

Mitesh V. Badiwala, BSc, MD=

Toronto, Ontario, M5= S 3A3

E-mail: mitesh.badiwala@utoronto.ca

Educ= ation and Training

November 2000<= span style=3D'mso-tab-count:2'> &= nbsp; &nbs= p;

Bachelor of Science – Summa Cum Laude

Arts & Science Program

= McMaster<= /st1:PlaceName> University, Hamilton, Ontario

Ju= ne 2004

Doctor of Medicine with Honours

University= of Tor= onto, Toronto, Ontario

Ju= ly 2004 - Present

Cardiac Surgery Residency Program

Royal College of Physicians a= nd Surgeons of Canada

University= of Tor= onto, Toronto, Ontario

Ju= ly 2006 - Present

PhD Candidate

Institute of Medical Science

Cardiovascular Sciences Collaborative Program

University= of Tor= onto, Toronto, Ontario

Supervisors: Drs. Viv= ek Rao and Terrence Yau, Division of Cardiac Surgery

Ju= ly 2006 - Present

Royal College of Physicians a= nd Surgeons of Canada

Clinician-Investigator Program

University= of Tor= onto, Toronto, Ontario

Ju= ly 2006 - Present

Surgeon-Scientist Program

Department of Surgery

University= of Tor= onto, Toronto, Ontario

Rese= arch and Teaching

June 2002 R= 11; August 2002

June 2001 R= 11; August 2001

Cardiac Surgery Summer Research Projects

Toronto General Hospital, Division of Cardiac Surgery, T= oronto, Ontario

§Supervisors:

Dr. Richard Weisel, Professor & Chair, Division of Cardiac Surgery

Dr. Subodh Verma, Scientist & Resident, Division of Cardiac Surgery

Dr. Ren-Ke Li, Professor, Division of Cardiac Surgery

&= sect;      =    Major Projects includ= ed:

·= ;      =    Investigating the rol= e of C-Reactive Protein on endothelial function and its role in the pathophysiol= ogy of atherosclerosis

·= ;      =    Researching the development of Academic Cardiac Surgery in Canada

·= ;      =    Identifying issues concerning Technology Transfer in Cardiac Surgery

May 2000 ̵= 1; August 2000

Undergraduate Biochemistry Summer Research Proj= ect

McMaster University Department of Biochemistry, Hamilton, Ontario

§      =    Supervisor: Dr. Richard Epand, Professor, Depa= rtment of Biochemistry

§Focused on biophysical properties of membranes and how they affect the activity of Diacylglycerol Kinase-e and Protein Kinase C-a in vitro.

January 2000 – April 2000

Statistics Teaching Assistant

McMaster University Department of Mathematics & Statistics, Hamilton, Ontario

§Computer Lab T.A. for= an Introductory Statistics course under Dr. F.M. Hoppe, Professor, Department of Mathematics & Statistics, McMaster University

Honours and Awards

= &nbs= p;

·        Vanier Canada Graduate Scholarship – Government of Canada (2009)

·        CIHR Doctoral Research Award - CIHR (2009)

·        Canadian Cardiac Transplant Network Research Award (2009)

·        CCS Basic Science Stu= dent Presentation Award Finalist – Canadian Cardiovascular Society (2008)<= o:p>

·        Starr Medal – Faculty of Medicine, University of Toronto (2008)

·        Edward Christie Steve= ns Fellowship – Faculty of Medicine, University of Toront= o (2008)

·        Joseph M. West Family Memorial Fund Award – Faculty of Medicine, University of Toronto (2008)

·        Chisholm Memorial Fellowship – Faculty of Medicine, University of Toronto (2008)

·        Canadian Cardiac Transplant Network Research Award (2008)

·        Bigelow Book Prize – Cardiovascular Sciences Collaborative Program, University of Toron= to (2008)

·      = The Government of Ontario/Wellesley Surgeons Graduate Scholarships in Science and Technology (2007)

·        Johnson & Johnson Medical Products Surgeon Scientist Program Fellowship (2007)

·        Alpha Omega Alpha Hon= or Medical Society (2004)

·        Walter F. Watkins Scholarship – Faculty of Medicine, University of Toronto (2003)

·        “Have a Heart” Bursary – Canadian Cardiovascular Academy (2002)

·        Rx&D Health Resea= rch Foundation Medical Student Research Award (2002)

·        Banting and Best Diab= etes Centre Summer Studentship (2002 – Declined)

·        Walter F. Watkins Scholarship – Faculty of Medicine, University of Toronto (2001)

·        Heart & Stroke Foundation of Ontario Medical Student Research Scholarship (2001)

·        NSERC Undergraduate S= tudent Research Award (2000)

·        The Dr. Harry Lyman Hooker In-Course Scholarship – McMaster University (1999)

·= ;      = Golden Key National Honour Society (1998)

·      = Regional Municipality of Hamilton-Wentworth – McMaster University Entrance Scholarship (1997)

Grants Funded

Telomerase Regulation by C-Reactive Protein

Principal Investigator – Dr. Mitesh V. Badiwala=

Supervisor/Co-Applicant – Dr. Richard D. Weisel=

The Physicians’ Serv= ices Incorporated Foundation

Research Grant – Total Amount Awarded $20,000
Support Period – 09/2005 to 09/2006

Cardiac Allograft Vasculopathy:&n= bsp; Determining Optimal Immunosuppression and Vascular Protection Strategies

Principal Investigator – Dr. Mitesh V. Badiwala

Supervisor/Co-Applicant – Dr. Vivek Rao

The Physicians’ Serv= ices Incorporated Foundation

Research Grant – Total Amount Awarded $20,000
Support Period – 07/2007-07/2008

Papers in Revision

Badiwala MV, Verma S, Rao V. Surgical Management of Ischemic Mitral Regurgitation. Revisions in progress for resubmission to Circulation, April 2009.

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Papers in Press

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Badiwala MV, Ramzy D, Tumiati LC, Tepperman ED, Sheshgiri R, Prodger J, Feindel CM,= Rao V. Donor Pretreatment wi= th Hypertonic Saline Attenuates Primary Allograft Dysfunction. Accepted for publication in Circulation, March 2008.=

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Published Papers =

1.      Badiwala MV, Rao V. = Left Ventricular Device as Destination Therapy: Are we there yet? Curr. Opin. Cardiol. 2009;24:184-189.

2.&n= bsp;     Sheshgiri R, Rao V, Tumiati LC, Xiao R, Prodger= JL, Badiwala MV, Librach C, Delgado DH. Progesterone Induces Human Leukocyte Antigen-G Expression in Vascul= ar Endothelial and Smooth Muscle Cells.&n= bsp; Circulation. 2008 Sep 30;118(14 Suppl):S58-64.

3.&n= bsp;     Ramzy D, Tumiati LC, Tepperman E, Sheshgiri R, Jackman J, Badiwala MV, Rao V.= Dual Immunosuppression Enhances Vasomotor Injury: Interactive Effect between Endothelin-1 and Nitric Oxide Bioavailability. J Thorac Cardiovasc Surg. 2008;135:938-44.

4.&n= bsp;     Lad VS, Rao V, Badiwala MV, and Jackman J. Stem-Cell Therapy for Ischaemic Cardiomyopathy. Indian Heart Journal 2007;59:B133-B142.

5.&n= bsp;     Badiwala= MV, Ross H= J, Rao V. An Unusual and Fatal Complication of Mechanical Circulatory Support with a Continuous Flow Assist Device.&= nbsp; N Engl J Med 2007;357:936-9= 37.

6.      Badiwala MV= , and Rao V. Tricuspid Valve Surgery after Cardiac Transplantation. Curr. Opin. Cardiol. 2007;22:123-127.

7.      Alsoufi B, Karamlou T, Osaki M, Badiwala MV, Ching CC, Dipchand A, McCrindle BW, Coles JG, Caldarone CA, Williams WG, Van Arsdell GS.= Surgical Repair of Multiple Muscular Ventricular Septal Defects: The Role of Re-endocardialization Strategy. J Thorac Cardiovasc Surg. 2006;132:1072-1080.

8.      Verma S, Kuliszewski MA, Li SH, Szmitko PE, Zucco L, Wang CH, Badiwala MV, Mickle DA, Weisel RD, Fedak PW, Stewart DJ, Kutryk MJ. C-Reactive Protein Attenuates Endothelial Progenitor Ce= ll Survival, Differentiation, and Function: Further Evidence of a Mechanistic = Link Between C-Reactive Protein and Cardiovascular Disease. Circulation. 2004;109:2058-2067.

9.      Verma S, Fedak PW, Weisel RD, Szmi= tko PE, Badiwala MV, Bonneau D, Latter D, Errett L, LeClerc Y. O= ff-pump coronary artery bypass surgery: fundamentals for the clinical cardiologist.= Circulation. 2004;109:1206-1211.

10. Verma S, Badiwala MV, Weisel RD, Li SH, Wang CH, Fedak PWM, Li RK, Mickle DAG. C= -Reactive Protein Activates the NF-kappa B Signal Transduction Pathway in Saphenous V= ein Endothelial Cells: Implications for Atherosclerosis and Restenosis.<= /i> J Thorac Cardiovasc Surg. 2003;126:1886-1891.

11. Dhillon B, Badiwala MV, Maitland A, Rao V, Li SH, Verma S. <= /span>Tetrahydrobiopterin Attenuates Homocysteine-Induced Endothelial Dysfunction. Mol Cell Biochem. 2003;247:223-227.

12. Dhillon B, Badiwala MV, Li SH, Li RK, Weisel RD, Mickle DAG, Fedak PWM, Rao V, Verma S. Caveolin: a key target for modulating nitric oxide availability in health and disease. Mol Cell Biochem. 2003;247:101-109.

13. Verma S, Yuen VG, Badiwala = MV, Anderson TJ, McNeill JH. Working heart function in diabetes is = not improved by spironolactone treatment.&= nbsp; Can. J. Physiol. Pharmacol. 2003;81:493-496.

14. Verma S, Wang CH, Weisel RD, Badiwala MV, Li SH, Fedak PWM, Li RK, Mickle DAG. Hyperglycemia Potentiates the Proatherogenic Effects of C-Reactive Protein: Reversal with Rosiglitazone. J Mol Cell Cardiol. 2003;35:417-419.

15. Verma S, Badiwala MV, H= ong NL. Fever and a New Heart Murmur.&= nbsp; Perspectives in Cardiology. September 2002.

16. Verma S, Wang CH, Li, SH, Weisel RD, Dumont AS, Fedak P= WM, Badiwala MV, Dhillon B, Li RK, Mickle D= AG, Stewart DJ. A Self-Fulfilling Prophesy: C-Reactive Protein Attenuates Nitric Ox= ide Production and Inhibits Angiogenesis.&= nbsp; Circulation. 2002;106:913-919.

17. Verma S, Li SH, Badiwala MV, Weisel RD, Fedak PWM, Li RK, Dhillon B, Mickle DAG. Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effect= s of C-Reactive Protein. Circulation. 2002;105:1890-1896.

18. Ko L, Maitland A, Fedak PWM, Dumont AS, Badiwala MV, Lovren F, Triggle CR, Anderson TJ, Rao V, Verma S. Endothelin receptor blockade potentiates the endothelial protective effects of ACE inhibitors in saphenous veins. Ann Thorac Surg. 2002;73:1185-1188.

19. Lam C, Badiwala MV, Froeschl M. Morning Report – “Truth Serum”. UTMJ. 2002;79:136-141.

Abstracts and Presentations

1.      Badiwala= MV, Zener R, Tumiati LC, Prodger JL, Sheshgiri R, Rao V. Egfl7 suppresses ICAM-1 expression in response to H/R injury and Tacrolimus.<= span style=3D'mso-spacerun:yes'> Presented at the Annual Meeting of= the International Society for Heart and L= ung Transplantation 2009.

2.      Ramzy D, Tumiati LC, Badiwala MV, Tepperman ED, Sheshgiri R, Rao V. Recipient Hypertonic Saline Infusi= on Prevents Cardiac Allgraft Dysfunction.&nbs= p; Presented at the Annual Meeting of the International Society for Heart and Lung Transplantation 2009.

3.      Badiwala= MV, Tepperm= an ED, Sheshgiri R, Prodger JL, Tumiati LC, Delgado DH, Ross HJ, Rao V. Rapamycin Withdrawal versus Delayed Initiation: Thrombosis vs. Suppression of Neointi= mal Hyperplasia after Vascular Injury.&nbs= p; Presented at the Annual Meeting of the Canadian Cardiovascular Society 2008.<= /p>
4.      Badiwala= MV, Tumiati= LC, Prodger JL, Sheshgiri R, Tepperman E, Rao V. Rapamycin Modulates Endothelial Response to Hypoxic Injury: Preserving Telomerase Activity and Stimulating Egfl7 Production. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2008<= /b>.

5.      Badiwala= MV, Rao V, B= obiarski J, Newcomb A, Ross HJ, Nanthakumar K, Cusimano RJ. Prophylactic LV Epicardial Leads in Patients with Poor = LV Function Under= going Cardiac Surgery: Does it make sense to capture these patients? Presented at the Annual Meetin= g of the Canadian Cardiovascular Societ= y 2008.

6.      Badiwala= MV, Maganti= M, Sheikh AM, Rao V. Mitral Valve Surgery Predicts Morbidit= y and In-Hospital Mortality in Patients Undergoing Left Ventricular Aneurysmectom= y. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2008<= /b>.

7.      Lazier JS, Tepperman ED, Badiwala MV, Prodger JL, Sheshgiri R, Tumiati LC, Rao V. Visfatin causes Coronary Artery Endothelial Cell Injury but Not Upregulation of Cell Adhesion Molecule Expression. Presented at the Annual Meeting of the Canadian Cardiovascular Society 2008.<= /p>
8.      Maganti M, Brister SJ, Yau TM, Collins S, Badiwala MV, Rao V. Changing Trends in Emergent Coronary Bypass Surgery. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2008<= /b>.

9.      Maganti M, David TE, Feindel CM, Scully H, Badiwala MV, Sheikh AM, Rao V. Predictors of Low Cardiac Output Syndrome After Mitral Valve Surgery. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2008<= /b>.

10. Badiwala= MV, Ramzy D, Tumiati LC, Tepperman ED, Sheshgiri R, Prodger JL, Feindel CM, Rao V. Donor Pretreatment with Hypertonic Saline Attenuates Primary Cardiac Allograft Dysfunction. Presented at= the Annual Meeting of the American Hea= rt Association 2008.

11. Badiwala= MV, Tepper= man ED, Sheshgiri R, Prodger JL, Delgado DH, Tumiati LC, Ross HJ, Rao V. Rapamycin Withdrawal versus Delayed Initiation: Thrombosis vs. Suppression of Neointi= mal Hyperplasia after Vascular Injury.&nbs= p; Presented at the Annual Meeting of the American Heart Association 2008. <= /p>
12. Badiwala= MV, Ramzy D, Tumiati LC, Tepperman E= D, Sheshgiri R, Prodger JL, Feindel CM, Rao V. Donor Pretreatment with Hypertonic Saline improves Coronary Artery Vascular Funct= ion Post-Cardiac Transplantation. Presented at the Annual Meeting of the International Society for Heart and Lung Transplantation 2008.

13. Badiwala= MV, Li SH,= Prodger JL, Tumiati LC, Li RK, Wei= sel RD, Rao V. Rapamycin Attenuates Hypoxic Inhibition of Telomerase Activity in Endothelial Cells. Presen= ted at the Annual Meeting of the Internat= ional Society for Heart and Lung Transplantation 2008.

14. Badiwala= MV, Tumiat= i LC, Prodger JL, Sheshgiri R, Tepperman ED, Ramzy D, Rao V. Hypoxic Injury and Rapamycin Stimulates Endothelial Chemoattractant Egfl7 Productio= n. Presented at the Annual Meeting of= the International Society for Heart and L= ung Transplantation 2008.

15. Sheshgiri R, Rao V, Tumiati LC, Badiwala MV, Tepperman ED, Prodge= r JL, Ramzy D, Delgado DH. Soluble HLA-G Is Negatively Associated with Allograft Rejection Following Heart Transplantation. Presented at the Annu= al Meeting of the International Socie= ty for Heart and Lung Transplantation 2008.

16. Tepperman ED, Lazier J, Tumiati LC, Ramzy D, Badiwala MV, Sheshgiri R, Jackman= JL, Ross HJ, Rao V. The Effect of Calcineurin Inhibition on Vasomotor Function and Visfatin Express= ion.&= nbsp; Presented at the Annual Meeting of the International Society for Heart and Lung Transplantation 2008.

17. Sathya CJ, Sheshgiri R, Prodger JL, Tumiati LC,= Badiwala MV, Tepperman ED, Lazier= J, Delgado DH, Rao V. Correlation between Circulating Endothelial Progenitor Cells and Allograft Rejection in Heart Transplant Patients. Presented at the Annu= al Meeting of the International Socie= ty for Heart and Lung Transplantation 2008.

18. Ramzy D, Tumiati LC, Xu N, Tepperman ED, Delgado DH, Jackman JL, Sheshgiri R, Badiw= ala MV, Rao V. Endothelin-1 antagonism prevents CyA induced vasomotor impairment: Implication for transplant related vascular injury. = Presente= d at the Annual Meeting of the International Society for Heart and Lung Transplantation 2008.

19. Badiwala= MV, Tumiat= i LC, Jackman J, Sheshgiri R, Tepperman ED, Rao V. Rapamycin modulates Endothelial response to Hypoxic Injury: Preserving Telomerase Activity and Stimulating Egfl7 Production. Presented at the Annual Meeting of the Canadian Society of Transplantation 2008.

20. Ramzy D, Badiwala MV, Tumiati LC, Tepperman ED, Sheshgiri R, Jackman J, Feindel CM, Rao V. Recipient Hypertonic Saline Infusion Prevents Primary Cardiac Allog= raft Dysfunction. Presented at= the Annual Meeting of the Canadian Soc= iety of Transplantation 2008.

21. Ramzy D, Tumiati LC, Badiwala MV, Tepperman ED, Sheshgiri R, Jackman J, Rao V. Hypoxia and Reperfusion: Role Of Protein kinase C And eNOS In Free Radical Generati= on. Presented at the Annual Meeting of the Canadian Society of Transplantation 2= 008.

22. Prodger JL, Tumiati LC, Badiwala MV, Sheshgiri R, Tepperman ED, Waddell T, Rao V.&nbs= p; Integrin and Adhesion Molecule Profiling of Human Endothelial Progen= itor Cells. Presented at the A= nnual Meeting of the Canadian Society of Transplantation 2008.

23. Tepperman ED, Lazier J, Tumiati LC, Ramzy D, Badiwala MV, Sheshgiri R, Jackman= JL, Ross HJ, Rao V. The Effect of Calcineurin Inhibition on Vasomotor Function and Visfatin Express= ion.&= nbsp; Presented at the Annual Meeting of the Canadian Society of Transplantation 2008.

24. Sheshgiri R, Rao V, Tumiati LC, Prodger JL, Tepperman ED, Badiwala MV, Ram= zy D, Delgado DH. Soluble HLA-G is Negatively Associated with Allograft Rejection following Heart Transplantation. Presented at the Annual Mee= ting of the Canadian Society of Transplantation 2008.

25. Badiwala= MV. Preclinical Hypertonic Saline Studies in Cardiac Transplantation. Invited Guest Lecturer, Heart Transplant Research Rounds, Multi Organ Transplant Program, University Health Network, Toronto, ON. December 12, 2007.

26. Tepperman ED, Ramzy D, Tumiati LC, Badiwala MV, Sheshgiri R, Jackman= JL, Ross HJ, Rao V.&= nbsp; Tacrolimus Preserves = Endothelial-Dependent Vasomotor Function And Decreases Sensitivity To Vasospasm By Increasing Endothelin(B) Receptor Expression. Presented at the Annu= al Meeting of the American Heart Association 2007.

27. Sheshgiri R, Rao V, Tumiati LC, Ramzy D, Jackman JL, Tepperman ED, Badiwala MV, Delgado DH. Progesterone Induces = Human Leukocyte Antigen-G Expression in the Vascular Endothelium: A Potential Protective Strategy against Cardiac Allograft Rejection. Presente= d at the Annual Meeting of the American Hea= rt Association 2007.

28. Ramzy D, Tumiati LC, Badiwala MV, Tepperman ED, Sheshgiri R, Jackman JL, Rao V. Hypoxia and Reperfusion: Role Of Protein kinase C And eNOS In Free Radical Generati= on. Presented at the Annual Meeting of the American Heart Association 2007.<= /span>

29. Ramzy D; Tumiati LC, Sheshgiri R, Jackman JL, Badiwala MV, Tepperman ED, Rao V.= Isoform Specific PKC Responses Modulate ET-1 and Hypoxia Reperfusion Induced Injury. Presented a= t the Annual Meeting of the American Hea= rt Association 2007.

30. Badiwala= MV, Lad V,= Scully HE, David TE, Ross HJ, Rao V. Severe Left Ventricular Dysfunctio= n Does Not Preclude Successful Surgery for Isolated Tricuspid Valve Disease. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2007.=

31. Badiwala= MV, Ramzy = D, Tumiati LC, Tepperman ED, Sheshgiri R, Jackman JL, Feindel CM, Rao V. Donor Pretreatment with Hypertonic Saline improves Coronary Artery Vascular Funct= ion Post-Cardiac Transplantation. Presented at the Annual Meeting of the Canadian Cardiovascular Society 2007.

32. Rao V, Badiwala MV, Rodger M, MacIver J, Harwood S, Hemeon S, Cusimano RJ, Yau TM, Delg= ado DH, Ross HJ. Mechanical Circulatory Support as a Bridge to Transplant Candidacy:= A Word of Caution. Presente= d at the Annual Meeting of the Canadian Cardiovascular Society 2007.

33. Lad VS, Badiwala MV, Pelenghi S, Cusimano RJ, Yau TM, Delgado DH, Ross HJ, Harwood S, Rao V. Abiomed BVS 5000: The Toronto General Hospital Experience. Presented at the Annual Meetin= g of the Canadian Cardiovascular Society 2007.

34. Ramzy D, Badiwala MV, Tumiati LC, Tepperman ED, Sheshgiri R, Jackman J, Feindel CM, Rao V. Recipient Hypertonic Saline Infusion Prevents Primary Cardiac Allog= raft Dysfunction. Presented at= the Annual Meeting of the Canadian Cardiovascular Society 2007.

35. Ramzy D, Tumiati LC, Badiwala MV, Tepperman ED, Sheshgiri R, Jackman J, Rao V. Hypoxia and Reperfusion: Role of Protein Kinase C and eNOS in Free Radical Generati= on. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2007.=

36. Tepperman ED, Ramzy D, Tumiati LC, Badiwala MV, Sheshgiri R, Jackman= J, Ross HJ, Rao V. Tacrolimus Preserves Endothelial-Depen= dent Vasomotor Function and Decreases Sensitivity to Vasospasm. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2007.=

37. Ramzy D, Tumiati LC, Sheshgiri R, Jackman J, Badiwala MV, Tepperman ED, Rao V.= Isoform Specific PKC Responses Modulate ET-1 and Hypoxia Reperfusion Induced Injury= . Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2007.=

38. Sheshgiri R, Rao V, Ramzy D, Tumiati LC, Jackma= n J, Badiwala MV, Tepperman ED, Del= gado DH. Endomyocardial Expression of Human Leukocyte Antigen-G Correlates Significantly with Allograft Tolerance in Heart Transplant Patients. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2007.=

39. Ramzy D, Tumiati LC, Xu N, Tepperman ED, Jackman JL, Badiwala MV, Sheshgiri R, = Rao V. Dual Immunosuppression Enhances Vasomotor Injury: Interactive Effect Between Endothe= lin-1 and Nitric Oxide Bioavailability. Presented at the Annual Meeting of the American Association for Thoracic Surgery 2007.

40. Jackman JL, Partridge E, Ward M, Tumiati LC, Badiwala MV, Sheshgiri R, Stewart= D, Rao V. Hypoxia-Reperfusion Injury Increases Cell Specific Endothelial Progenitor Cell Adhesion in an ICAM-1 Dependent Manner. Presented at the Annual Meeting of= the International Society of Heart and Lu= ng Transplantation 2007.

41. Jackman JL, Tumiati LC, Xu N, Ramzy D, Sheshgir= i R, Badiwala MV, Rao V. Rapamycin Inhibits Endothelial Cell Recovery after Hypoxic Injury. Presented at the Annual Meeting of= the International Society of Heart and Lu= ng Transplantation 2007.

42. Ramzy D, Tumiati LC, Xu N, Tepperman E, Delgado= DH, Jackman J, Badiwala MV, Sheshg= iri R, Rao V. Endothelin-1 Exacerbates Hypoxic Injury through eNOS Derived Free Radical Production: Implication for Primary Allograft Dysfunction. Presented at the Annual Meetin= g of the International Society of Heart= and Lung Transplantation 2007.=

43. Ramzy D, Tumiati LC, Xu N, Tepperman E, Delgado= DH, Jackman J, Sheshgiri R, Badiwala M= V, Rao V. Endothelin-1 Antagonism Prevents CyA Induced Vasomotor Impairment:<= span style=3D'mso-spacerun:yes'> Implications for Transplant Related Vascular Injury. Presented at the Annual Meeting of the International Society of Heart and Lu= ng Transplantation 2007.

44. Badiwala= MV, Ramzy = D, Tumiati LC, Tepperman ED, Sheshgiri R, Jackman JL, Feindel CM, Rao V. Donor Pretreatment with Hypertonic Saline improves Coronary Artery Vascular Funct= ion Post-Cardiac Transplantation. Presented at the Annual Meeting of the Canadian Society of Transplantation 2007.

45. Sheshgiri R, Rao V, Tumiati L, Ramzy D, Jackman= J, Badiwala MV, Tepperman E, Xu N, D= elgado D. Analysis of Human Leukocyte Antigen-G Expression in the Vascular Endothelium. Presented at= the Annual Meeting of the Canadian Soc= iety of Transplantation 2007.

46. Sheshgiri R, Rao V, Butany J, Ramzy D, Tumiati = L, Jackman J, Badiwala MV, Tepper= man E, Delgado D. Human Leukocyte Antigen-G: A Novel Molecule Associated with Graft Tolerance Following Cardiac Transplantation. Presente= d at the Annual Meeting of the Canadian Society of Transplantation 2007.

47. Jackman J, Partridge E, Ward M, Tumiati L, Badiwala MV, Sheshgiri R, Stewart= D, Rao V. Hypoxia-Reperfusion Increases Cell Specific Endothelial Progenitor = Cell Adhesion in an ICAM-1 Dependent Manner.&nb= sp; Presented at the Annual Meeting of the Canadian Society of Transplantation 2007.

48. Ramzy D, Tepperman E, Tumiati LC, Xu N, Sheshgi= ri R, Jackman J, Badiwala MV, Del= gado DH, Ross HJ, Rao V. Dual Immunosuppression Enhances Vasomo= tor Injury: Interactive Effect Be= tween Endothelin-1 and Nitric Oxide Bioavailability. Presented at the Annual Meetin= g of the Canadian Society of Transplant= ation 2007.

49. Ramzy D, Tumiati LC, Xu N, Tepperman E, Jackman= J, Badiwala MV, Sheshgiri R, Rao V.<= span style=3D'mso-spacerun:yes'> Limiting Endothelial Cell Hypoxic Injury: The Role of Isoform Specific PKC Modulation. Pres= ented at the Annual Meeting of the Canad= ian Society of Transplantation 2007.

50. Ramzy D, Tumiati LC, Xu N, Tepperman E, Jackman= J, Badiwala MV, Sheshgiri R, Rao V.<= span style=3D'mso-spacerun:yes'> Endothelin-1 Antagonism and Nitric Oxide Augmentation Prevents CyA Induced Vasomotor Impairment: Implication for Transplant Related Vascular Injury. Presented at the Annual Meeting of the Canadian Society of Transplantation 2007.

51. Badiwala MV, Verma S, Li SH, Dhillon B, Weisel RD, Li RK, Mickle DAG. C-Reactive Protein Activates the NF-kappa B Signal Transduction Pathway in Human Saphe= nous Vein Endothelial Cells. P= resented at the Annual Meeting of the Canad= ian Cardiovascular Society 2003.

52. Badiwala MV, Li SH, Weisel RD, Li RK, Fedak PWM, Mickle DAG, Verma S. Hyperglycemia Exaggerates the Pro-Atherogenic Effects of C-Reactive Protein. Presented at the Annual Meeting of= the Canadian Cardiovascular Society 2002<= /b>.

53. Verma S, Ko L, Fedak PWM, B= adiwala MV, Cusimano RJ, Yau TM. = The St. Jude Medical Sutureless Aortic Anastomotic Connector (AAC) Does Not Impair Endothelial Function in Human Saphenous Veins. Presente= d at the Annual Meeting of the Canadian Cardiovascular Society 2002.

54. Verma S, Li SH, Weisel RD, = Badiwala MV, Fedak PWM, Dhillon B, Mickle DAG, Rao V, Li RK. Novel Cardioprotective Effects of Pravastatin in Human Ventricular Cardiomyocytes Subjected to Hypoxia and Reoxygenation: Beneficial Effects of Statins Independent of Endothelial Cells. Presented at the Annual Meeting of the Canadian Cardiovascular Society 2002.

55. Verma S, Li SH, Badiwala MV= , Weisel RD, = Fedak PWM, Stewart DJ, Li RK, Mickle DAG. The Proatherogenic Effects of C-Reactive Protein are linked to Increased Endothelin-1 and Interleukin-6 Release: A Novel Observation. Presented at the Annual Meeting of the Canadian Cardiovascular Society 2002.

56. Verma S, Ko L, Hyder T, Weisel RD, Badiwala MV, Fedak PWM, Li RK, Fremes SE. Bosentan: A Novel Approach to Radial Artery Vasospasm. Presented at the Annual Meeting of the Canadian Cardiovascular Society 2002.

57. Verma S, Mickle DAG, Weisel RD, Li SH, Badiwala MV, Lee TC, Fedak PWM, Li RK, Stewart DJ. C-Reactive Protein Quenches Nitric Oxide Release and Induces Endothelial Cell Apoptosis. Presented at t= he Annual Meeting of the Canadian Cardiovascular Society 2002.

58. Verma S, Badiwala MV, Li SH, Mickle DAG. PPAR-Gamma Agonists Counter the Atherogenic Effects of CRP: A Novel Observation. <= /span>Presented at the Annual Meeting of the American Heart Associ= ation 2002.

59. Verma S, Li SH, Badiwala MV, Weisel RD, Mickle DAG, Stewart DJ.= Unravelling the Mechanistic Basis of the CRP-Atherosclerosis Connection: Novel Role of Nitric Oxide (NO) and Endothelin-1 (ET-1). Presented at the Annual Meeting of the American Heart Association 2002.

60. Verma S, Badiwala MV, Li SH, Weisel RD, Mickle DAG. C-Reactive Protein is a Novel Mediator of Saphenous Vein Atherosclerosis: Molecular, Biochemical, Pharmacological and Gene Array Studies. Presented at the Annu= al Meeting of the Society for Vascular Medicine and Biology 2002.

61. Fremes SE, Verma S, H= yder T, Badiwala MV, Ko L, Fedak PW= M, Li RK, Weisel RD, Rao V. Bosentan: A Pharmacological Strategy f= or Severe Radial Artery Vasospasm. Presented at the Annual Meeting of the American College<= /st1:PlaceType> of Cardiology 2002.

62. Verma S, Li SH, Weisel RD, Fedak PWM, Badiwala MV, Mickle DAG, Rao V, Li RK. Novel Cardioprotective effects of Pravastatin following simulated Anoxia and Reoxygenation. Presented = at the Annual Meeting of the American Hea= rt Association 2001.

63. Badiwala MV, Verma S, Li SH, W= eisel RD, Fedak PWM, Rao V, Mickle DAG, Li RK. C-Reactive protein and atherosclerosis: Role of endothelin antagonism and IL-6 inhibition. Oral Presentation at the Toronto General Research Institute An= nual Research Day 2001.

Book Chapters

1.   &n= bsp; Badiwala MV= , and Rao V (2008). Management of Tricuspid Regurgitation after Cardiac Transplantation. Accepted for publication in Heart Transplantation: Indications and Contraindications, Procedures and Complications. Hauppauge, New York: Nova Science Publishers, Inc.

2.   &n= bsp; Badiwala MV, Borowiec AM, and Sun JC. (2004). Cardiac and Vascular Surgery. In A. Molckovsky and K. Pirzada (Eds.), MCCQE 2004 Review Notes. Toronto, Ontario: Toronto Notes Medical Publish= ing 2004 Inc.

<= span lang=3DEN-US style=3D'font-family:Arial;mso-fareast-font-family:Arial;font-= weight: normal'>3.      Badiwala MV. (2002). Child Labour in India: Causes, Governmental Policies, and the role of Education. In N.V. Chowdary (Ed.), Soft Infrastructure – Promise and Progress. (pp. 104-117). Hyderabad, India: IC= FAI Press.

Badiwala = MV, and Shahani R. (2002). The Peripheral Vascular Exam.&= nbsp; In S. Butalia, H.H. Ko, C. L= am and J. Tan (Eds.), Essentials of Clinical Examination Handbook. (pp. 215-229). Toronto= , Ontario: Medical Society, Faculty of Medicine, University of T= oronto.

Committee Leadership / Volunteer Activities

December 2007 &= #8211; Present

        &= nbsp;   University of Toronto Surgical Mentorship Program

§      =    Mentor for medical students at the University of Toron= to who are interested in careers in surgery

July 2005 ̵= 1; June 2006

        &= nbsp;   University of Toronto Division of Cardiac Surgery Residency Program Committee

§      =    Junior resident representative for the Cardiac Surgery Residents on the Residency Program Committee for the Division of Cardiac Surgery at the University= of Toronto

May 2003 –= ; December 2003

&nb= sp;           MCCQE 2004 Review Notes Cardiac & Vascular Surgery Chapter Editor<= /span>

§      =    Cardiac & Vascular Surgery Chapter editor for the upcoming 2004 edition of the Medical Council of Canada Qualifying Exam revi= ew notes

September 2002 = – September 2003

        &= nbsp;   Wightman-Berris Academy Representative<= /o:p>

§      =    Third-year medical student representative for the Wightman-Berris Acad= emy on the University of Toronto Medical Society Executive Board

February 2002 &= #8211; May 2002

        &= nbsp;   University of Toronto Saturday Program Tut= or

§         Volunteer Saturday morning tutor for inner-city high sc= hool students

September 2001 = – September 2002

        &= nbsp;   University of Toronto Medical Journal Morning Report Editor

§         Co-editor of the Morning Report section of the University of Toronto Medical Journal=

June 1999 R= 11; June 2000     &nbs= p;            &= nbsp;

McMaster= University Senate Committee on Student Affairs      =

§      =    Worked with the fellow committee members to recommend policies to the Senate, and review submissions on non-academic aspects of student life, and on matters of student conduct and discipline

Memberships and Associ= ations

&= sect;      =    Canadian Cardiovascul= ar Society

&= sect;      =    Amercan Heart Associa= tion

&= sect;      =    International Society= of Heart and Lung Transplantation

&= sect;      =    Canadian Society of Transplantation

&= sect;      =    Canadian Society of Cardiac Surgeons

&= sect;      =    Alpha Omega Alpha Hon= or Medical Society – Universit= y of Toronto

&= sect;      =    Golden Key National Honour Society – Mc= Master University

= §      =    Professional Association of Internes and Residents of <= st1:State w:st=3D"on">Ontario

&= sect;      =    The University of Toron= to Medical Alumni Association

&= sect;      =    McMaster University Alumni Association