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Cover: Side panels, top to bottom: nerve stimulation-evoked calcium signals in nerve terminals of the frog neuromuscular junction before (left) and after (right) application of the spider toxin ω-Ptx-IIA. The images show relative Ca2+ levels before, during, and after 60 Hz nerve stimulation. See Figure 3 in article by Troncone et al. Center panel: photograph of the Brazilian armed spider (Phoneutria nigriventer) in attack posture. The venom of this formidable predator contains many poisonous components including ω-Ptx-IIA which acts on calcium channels and can block synaptic transmission. Photo courtesy of Giuseppe Puorto, Instituto Butantan, Sao Paulo, Brazil. From: Troncone LR, Georgiou J, Hua S-Y, Elrick D, Magnoli IL, Charlton MP. Promiscuous and reversible blocker of presynaptic calcium influx in frog and crayfish neuromuscular junctions from Phoneutria nigriventer spider venom. J Neurophysiol. August 14, 2003; 10.1152/jn.00155.2003.