Publications

2016

U Kuzmanov, H Guo, J Cosme, R Isserlin, P Sharma, A.O Gramolini*, A Emili*. (2016). Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci (USA)113(44):12592-12597

Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, Robbins CS. (2016). Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth. Nature Immunology.17(2): 159-68.

Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Julius O, Nyalwidhe N, Gramolini AO, Lance RS,Troyer DA, Drake RR, Boutros PC, Semmes OJ and Kislinger T. (2016). Targeted proteomics identifies liquid biopsy signatures for extracapsular prostate cancer. Nature Communications.7: 11906.

Gramolini A, Lau E, Liu PP.(2016). Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases. Circulation. 116: 116.022940.

 

2015

Sharma P, Abbasi C, Bousette N, Lazic S, Dubois N, Ignatchenko A, Ignatchenko V, Teng A, Wilson A, Noronha M, Wong V, Liu J, Araki T, Liu J, Tiburcy M, Zimmerman WH, Ackerley C, Hamilton R, Sun Y, Liu P, Backx P, Keller G, Stagljar I, Scott I, Kislinger T, Gramolini AO. Tmem65 is an Evolutionary Conserved Membrane Protein that Regulates Cardiac GAP Junction communicationNature Communications. 2015; 10.1038/NCOMMS9391.

D.Spillane, *D.Y Wang, C. Shi, H.-R. Cho, H. Shimizu,Y. Wang, A.O.Gramolini, K. Stewart, S.Newbigging, M. Liu, and X.-Y. Wen. Chromosome Condensation 1-like gene is a novel tumor suppressor involved in development of histiocyte-rich neoplasms. PLoS One. 2015. 10(8):e0135755. doi: 10.1371.

Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O’Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH. Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types. PLoS One. 2015;10:e0127828.

Teng A, Miyake T, Yokoe S, Zhang, L, Rezende ML, Maclennan DH, Liu PP, Gramolini AO. Metformin Increases Degradation of Ubiquitinylated Phospholamban via Autophagy in Cardiomyocytes. Proc Natl Acad Sci (USA). 2015;112:7165-7170.

Isserlin R, Merico D, Wang D, Bousette N, Gramolini AO, Bader G, Emili A. Systems analysis reveals down-regulation of a network of pro-survival miRNAs drives the apoptotic response in dilated cardiomyopathy. Molecular BioSystems. 2015;11:239-251.

 

2014

N. Bousette, C. Abbasi, R.Chis, and A.O. Gramolini. Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis. J Cell Physiol. 2014;229(3):374-83.

Lu Z, Sinha A, Sharma P, Kislinger T, Gramolini, A. Proteomic Analysis of Human Fetal Atria and Ventricle. Journal of Proteome Research. 2014;13:5869-78.

Wang D, Abbasi C, El-Rass S, Li J, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH,  Cox B, Wen XY, Liu P, Gramolini AO. ERp44 deficiency in mice and zebrafish leads to cardiac developmental and functional defects. Journal of American Heart Association. 2014;3:e001018.

Burniston JG, Gramolini AO. Cardiac proteomics. Biomed Research International. 2014:903538.

Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nature Communications. 2014;5:3430.

Liang W , Huang L , Zhao D , He JZ , Sharma P , Liu J , Gramolini AO, Ward ME , Cho HC , Backx PH. Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells. Journal of hypertension. 2014;32(2):318-30.

 

2013

V.A. Fajardo, E. Bombardier, C. Vigna, T. Devji, D. Bloemberg, D. Gamu, A.O. Gramolini, J. Quadrilatero, A.R.Tupling (2013) Co-expression of SERCA Isoforms, Phospholamban and Sarcolipin in Human Skeletal Muscle Fibers PloS One 8(12):e84304

N. Bousette, C. Abbasi, R.Chis, and A.O. Gramolini.  Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis (2013) J Cell Physiol 229, 374-83

J. Cosme, P. Liu and A.O.Gramolini (2013) The Cardiovascular Exosome: Current Perspectives and Potential. Proteomics 13,1654-9

S. Chugh, M. Ouzounian, Z. Lu, S. Mohamed, P.Liu, and A.O. Gramolini.  Identification of potential biomarkers in human heart failure (2013). Proteomics 13,2324-34

Sun M, Ouzounian M, de Couto G, Chen M, Yan R, Fukuoka M, Li G, Moon M, Liu Y, Gramolini A, Wells GJ, Liu PP. Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways. J Am Heart Assoc. 2013 Apr 22;2(2):e000191. doi: 10.1161/JAHA.113.000191

 

2012

P. Sharma, J. Cosme, and A. O. Gramolini (2012) Recent advances in cardiovascular proteomics, J Proteomics. doi:pii: S1874-3919(12)00738-5. 10.1016/j.jprot.2012.10.026.

J.A. Hewel, S. Phanse , J. Liu, N. Bousette, A. Gramolini, and A. Emili (2012) Targeted protein identification, quantification and reporting for high-resolution nanoflow targeted peptide monitoring. J Proteomics  doi:pii: S1874-3919(12)00715-4. 10.1016/j.jprot.2012.10.020 .

Y. Kim, V. Ignatchenko, C.Q. Yao, I. Kalatskaya, J.O. Nyalwidhe, R.S. Lance, A.O. Gramolini, D.A. Troyer, L.D. Stein, P.C. Boutros, J.A. Medin, O.J. Semmes,  R. Drake and T.Kislinger (2012) Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. Mol Cell Proteomics 11, 1870-1884.

J. Cosme, A. Emili, and A.O. Gramolini (2012) Large scale characterization of the mouse cardiac proteome. Meth Mol Biol.

R. Chis, P.Sharma, N.Bousette, T.Miyake, A.Wilson , P.H.Backx, and A.O. Gramolini (2012) α Crystallin B interacts with VDAC, caspase 3 and caspase 12 to prevent apoptosis following H2O2 exposure in cardiomyocytes. Am J Physiol (Heart and Circ) 303, H967-978.

P. Sharma, U.Nair, W. Li, A. Dong, T. Miyake, A. Wilson, T.Ryan, T. Kislinger, S.Dhe-Paganon, and A.O.Gramolini (2012) Structural Determination of the Phosphorylation Domain of the Ryanodine Receptor.  Febs J 279, 3952-3964.

P.J. Rugg-Gunn, B.J. Cox, F. Lanner, P. Sharma, V. Ignatchenko, A.C. McDonald, J. Garner, A.O. Gramolini, J. Rossant, T. Kislinger (2012) Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells. Developmental Cell 22, 887-901.

S. Chugh, P. Sharma, T. Kislinger and A. Gramolini (2012) Clinical proteomics: getting to the heart of the matter. Circulation: Cardiovascular Genetics 5, 377.

O.A. Mulyar, A.C. Teng, A.O. Gramolini (2012) A proteomic interrogation of Cryptococcus neoformans: interaction networks for calcineurin in a heated environment. Exp Rev Proteomics 9, 13-15.

 

2011

N. DuBois, A. Craft, P. Sharma, A. Elephanty, E. Stanley, D. Elliott, A. Gramolini, and G. Keller (2011) Novel use for SIRPA as a specific cell surface marker for the isolation of human pluripotent stem cell-derived cardiomyocytes. Nature Biotechnology 29, 1011-1018.

T. Miyake, J.C. McDermott, and A.O. Gramolini (2011) A Method for the Direct Identification of Differentiating Muscle Cells by a Fluorescent Mitochondrial Dye. PLoS  One 6, e28628.

B. Cox, P. Sharma, A. Evangelou, K. Whitely, V. Ignatchenko, A. Ignatchenko, D. Baczyk, M. Czikk, J. Kingdom, J. Rossant, A. Gramolini, S.L. Adamson, and T. Kislinger (2011) Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia. Mol Cell Proteomics 10, Epub: M111.012526

A.R. Tupling, D. Hussain, M.G. Trivieri, S.C. Gupta, G. Babu, P.H. Backx, M. Periasamy, D.H. MacLennan and A.O. Gramolini (2011) Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice. AJP Cell 301, C841-849.

Y.Kim, S. Elsenbroich, P. Sharma, L. Sepiashvili, A.O. Gramolini and T. Kislinger (2011) Use of colloidal silica-beads for the isolation of cell surface proteins for mass spectrometry-based proteomics. Meth Mol Biol 748, 227-241

S.Elschenbroich, V.Ignatchenko, B.Clarke, S.E. Kalloger, P.C.Boutros, A.O.Gramolini, P.Shaw, I.Jurisica and T. Kislinger (2011) In-depth proteomics of ovarian cancer ascites: Combining shotgun proteomics and selected reaction monitoring mass spectrometry. J Proteom Res 6, 2286-2299

T. Ryan, P. Sharma, D.H. MacLennan, T.Kislinger, and A.O. Gramolini. (2011) Ryanodine receptor interactions identified using affinity purifications coupled with mass spectrometry: Implications for calcium homeostasis. J Biol Chem 286, 17060-17068.  Best Paper of 2011 in JBC

M. Sun, M. Chen, Y. Liu, M. Fukuoka, K. Zhou, G. Li, F. Dawood, A.O. Gramolini, and PP Liu (2011) Cathepsin-L contributes to cardiac repair and remodelling post-infarction. Cardiovas Res 89, 374-383 (DOI: 10.1093/cvr/cvq328)

P. Sharma*, T. Shathasivam*, V. Ignatchenko, T.Kislinger, and A.O. Gramolini. (2011) Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein–protein interaction analysis. Mol Biosys 7, 1185-96 (DOI: 10.1039/c0mb00235f).

 

2010

N. Bousette, S. Chugh, V.Fong, R. Isserlin, K. Kim, A. Volchuk, P.H. Backx, P.Liu, T.Kislinger, D.H. MacLennan, A. Emili, and A.O. Gramolini (2010). Mechanisms of calcineurin mediated cyto-protection in cardiac muscle identified through exhaustive MuDPIT proteomics. Proc Natl Acad Sci (USA) 107, 18481-18486.

T. Shathasivam, P. Sharma, T.Kislinger, and A.O. Gramolini (2010). Genes, proteins and complexes: The multifaceted nature of FHL family proteins in diverse tissues. J Cell Mol Med (DOI: 10.1111/j.1582-4934.2010.01181.x. ) 

T. Kislinger and A.O. Gramolini (2010) Proteome analysis of mouse model systems: A tool to model human disease and for the investigation of tissue-specific biology. J Proteomics 73, 2205-2218.

P. Sharma, V. Ignatchenko, K. Grace, C. Ursprung,  T. Kislinger, and A.O Gramolini (2010) Endoplasmic reticulum protein targeting of phospholamban: A common role for an N-terminal di-arginine motif in ER retention? PloS One 5, e11496.

S. Chugh, C. Suen, and A.O. Gramolini (2010) Proteomics and mass spectrometry: What have we learned about the heart? Curr Cardiol Rev 6, 124-133 .

R. Isserlin, D. Merico, A.O. Gramolini, G.D. Bader, and A.Emili (2010) Pathway analysis of heart disease via global proteomic profiling and enrichment maps. Proteomics 10, 1316-1327 . Research was highlighted as a Featured Article in Proteomics 10, 1103

S. Chugh, M. Ouzonian, P. Liu, and A.O. Gramolini (2010) Novel diagnoses and treatments in myocardial infarctions in  Myocardial ischemia: Causes, Symptoms and Treatment (NovaScience Publishers, New York) pp. 243-256

 

2009

Y. Maekawa, N. Mizue, A. Chan, Y. Shi, Y. Liu, S. Dawood, M. Chen, F. Dawood, G. de Couto, G. Hua Li, N. Suzuki, W-C. Yeh, A.O. Gramolini, J.A. Medin, and P. Liu (2009) Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 Receptor Associated Kinase-4 (IRAK-4) signaling: A regulator of bone marrow-derived dendritic cells. Circulation 120, 1401-1414.

S. Elsenbroich, V. Ignatchenko, P. Sharma, A.O. Gramolini and T. Kislinger (2009) Peptide separations by on-line MudPIT compared to immobilized pI strips: Application to C2C12 mouse skeletal muscle cells. J Proteome Res 8, 4860-4869.

N. Bousette W. Al-Ramli, J. Genest, S.T. Qureshi, Z. You, M. Gaffar, A.O. Gramolini, D. Behm, E. H. Ohlstein, S. M. Harrison, S. A. Douglas, and A. Giaid (2009) Urotensin II receptor knockout mice on an ApoE knockout background fed on high-fat diet exhibit enhanced hyperlipidemic and atherosclerotic phenotype. Circ Res 105, 686-695. 

S. Singh and A.O. Gramolini (2009) Identification and characterization of human TWIST. BMC Cell Biol 10:47 [PMID: 19534813]

N. Bousette, T. Kislinger, R. Isserlin, V. Fong, A. Emili, and A.O. Gramolini (2009) Defining the cardiac proteome by gel-free expression proteomics and microarray analyses. J Proteome Res 8, 1887-1901.

S. Chugh, P. Liu, A. Emili, and A.O. Gramolini (2009) Biomarkers for personalized medicine for cardiovascular diseases. Expert Op Med Diagnost 3,1-9

 

2008

A. O. Gramolini, S Pederman and T. Kislinger (2008) Mass-spectrometry based proteomics: A useful tool for biomarker discover. Clin Pharmacol Therapeutics 83, 758-760

Y. Zhu*, A.O. Gramolini*, H.Sun, A.D. Mori, Y. Zhu, P.H. Backx, D.H. MacLennan, and B.G. Bruneau. (2008) Holt–Oram syndrome Tbx5 mutations regulate ventricular diastolic function via downregulated SERCA2 activity. Proc Natl Acad Sci (USA) 105, 5519-5524 

N. Bousette, A.O. Gramolini and T. Kislinger. (2008) Proteomic pathways in animal models. Proteomics – Clinical Applications 2, 638-653

M. Ouzounian, D. Lee, A.O. Gramolini, A. Emili, M. Fukuoka and P. Liu. (2008) Predict, prevent and personalize: Genomic and proteomic approaches to cardiovascular medicine. Can J Cardiol 23, 28-33.

 

2007

A.O. Gramolini*, T. Kislinger*, R. Alikhani-Koopaei, V. Fong, N.J. Thompson, R. Isserlin, P. Sharma, G.Y. Oudit, M.G.Trivieri, A. Fagan, A. Kannan, D. Higgins, H. Huedig, G. Hess, S. Arab, J. Seidman, C. Seidman, B. Frey, M. Perry, P.H. Backx, P.P. Liu, D.H. MacLennan, and A. Emili (2007) Comparative proteomic profiling of a phospholamban mutant mouse model of heart failure reveals progressive intracellular stress responses associated with dilated cardiomyopathy. Mol Cell Proteomics 7, 519-533 .

E. Zvaritch, F. Depreux, N. Kraeva, R.E. Loy, S.A. Goonasekera, S. Boncompagi, A. Kraev, A.O. Gramolini, R.T. Dirksen, C. Franzini-Armstrong, C.E. Seidman, J.G. Seidman and D.H. MacLennan (2007) A Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proc Natl Acad Sci (USA) 104, 18537-18542.

A.O. Gramolini and A. Emili. (2007) Discovery of biomarkers in cardiovascular disease. Clinical Proteomics 231-239.

 

2006

S. Arab, A.O. Gramolini, P. Ping, T. Kislinger, B. Stanley, J. van Eyk, D.H. MacLennan, A.Emili and P.P. Liu. (2006) Cardiovascular proteomics: Tools to develop novel biomarkers and potential applications. J Am Coll Cardiol 48, 1733-1741.

A. O. Gramolini, T. Kislinger, P.P. Liu, D.H. MacLennan and A. Emili. (2006) Analyzing the cardiac muscle proteome by liquid chromatography-mass spectrometry (LC-MS) based expression proteomics. Method Mol Biol 357, 15-32.

T. Kislinger, B. Cox, A. Kannan, C. Chung, P.Hu, A. Ignatchenkop, M.S. Scott, A.O. Gramolini, Q. Morris, M. Hallett, J. Rossant, T. Hughes, B.Frey, and A. Emili. (2006) Global survey of organ and organelle protein expression in mouse: Combined proteomic and transcriptomic profiling. Cell 125, 173-186.

M.G. Trivieri, G.Y. Oudit, R. Sah, B.G. Kerfant, H. Sun, A.O. Gramolini, Y. Pan, A.D. Wickenden, W. Croteau, G. M.Escobar, D. St.Germain, R. Pekhletski, D.H. MacLennan, and P.H. Backx (2006) Cardiac-specific elevations in thyroid hormone enhances contractility and prevents pressure-overload induced cardiac dysfunction. Proc Natl Acad Sci (USA) 103, 6043-6048.

A. O. Gramolini, M.G. Trivieri, G.Oudit, P.H. Backx, and D.H. MacLennan. (2006) Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Proc Natl Acad Sci (USA) 103, 2446-2451.

K. Haghighi, F. Kolokathis, A.O. Gramolini, J. Waggoner, L.Pater, R.A. Lynch, G.C. Fan, D.Th. Kremastinos, D.H. MacLennan, and E.G. Kranias (2006) A mutation in the human phospholamban gene deleting arginine 14 results in lethal, hereditary cardiomyopathy.  Proc Natl Acad Sci (USA) 103, 1388-1393.

A. O. Gramolini and A. Emili. (2005) Uncovering early markers of heart failure using proteomics. Expert Rev Proteomics 2, 631-614.

 

Publications from Postdoctoral Training

 

T. Kislinger, A. O. Gramolini, D.H. MacLennan and A. Emili. (2005) Multidimensional Protein Identification Technology (MudPIT): Technical overview of a method optimized for the comprehensive molecular investigation of normal and diseased heart tissue. J Am Soc Mass Spec 16, 1207-1220.

T. Kislinger*, A. O. Gramolini*, Y. Pan*, K. Rahman, D.H. MacLennan and A. Emili. (2005) Proteome dynamics during myogenic differentiation of C2C12 muscle cells. Mol Cell Proteomics 4, 887-901. *Equal first authors.

A.O. Gramolini, T. Kislinger, M. Asahi, W. Li, A. Emili and D.H. MacLennan (2004) Sarcolipin retention in the endoplasmic reticulum is dependent on its C-terminal amino acid motif, RSYQY and sarco(endo)plasmic Ca2+ ATPase. Proc Natl Acad Sci (USA) 101, 16807-16812.

A.R. Tupling, A.O. Gramolini, T.A. Duhamel, H. Kondo, M. Asahi, S.C. Tsuchiya, M.J Borelli, J.R. Lepock, K. Otsu, M. Hori, D.H. MacLennan, and H. Green. (2004) HSP70 binds to the skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) and prevents thermal inactivation. J Biol Chem 279, 52382-52389.

M.Asahi, K. Otsu, H. Nakayama, S. Hikoso, T. Takeda, A.O. Gramolini, T.Morita, Y. Kusakari, S. Hirano, K. Hongo, S. Hirotani, O. Yamaguchi, A. Peterson, S. Kurihara, M. Hori, and D.H. MacLennan. (2004) Cardiac-specific overexpression of sarcolipin inhibits SERCA2a activity and impairs cardiac function in mice. Proc Natl Acad Sci (USA) 101, 9199-9204.

Y. Pan*, T. Kislinger*, A.O. Gramolini*, E. Zvaritch, E.G .Kranias, D.H. MacLennan and A. Emili. (2004) Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics. Proc Natl Acad Sci (USA) 101, 2241-2246. *Equal first authors.

K. Haghighi, F. Kolokathis, L. Pater, R.A. Linch, M. Asahi, A. O. Gramolini, G. Fan, D. Tsiapras, H.S. Hahn, S. Adamopoulos, S. B. Liggett, G. W. Dorn, D.H. MacLennan, D.Th. Kremastinos, and E.G. Kranias (2003) Human phospholamban null results in lethal dilated cardiomyopathy: Critical difference between mouse and man. J Clin Invest 111, 869-876.

P.J. Mohler, J.J. Schott, A. O. Gramolini, K. Dilly, S. Guatimosim, W. H. DuBell, L.S. Song, K. Haurogne, F. Kynd, M.E. Ali, T. B. Rogers, W.J. Lederer, D. Escande, H. LeMarec, and V. Bennett. (2003) Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature 421, 634-639.

P. J. Mohler*, A. O. Gramolini*, and V. Bennett. (2002) Ankyrins. J. Cell Sci.115, 1565 1566. *Equal first authors.

P. J. Mohler*, A. O. Gramolini*, and V. Bennett. (2002) The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal IP3 and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. J Biol Chem 277, 10599-10607. *Equal first authors.

 

Publications from Graduate Training

B.J. Jasmin, L.A. Angus, G. Belanger, J.V. Chakkalakal, A.O. Gramolini, J.A. Lunde, M.A. Stocksley, and J. Thompson. (2002) Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: Insights into a therapeutic strategy for Duchenne muscular dystrophy. J Physiol (Paris) 96, 31-42.

A. O. Gramolini, G. Bélanger, and B.J. Jasmin. (2001) The 3' untranslated region (UTR) regulates the stability and targeting of utrophin mRNAs in skeletal muscle. J Cell Biol 154, 1173-1183.

A. O. Gramolini, G. Bélanger, J. Chalakkal, J. Thompson, and B.J. Jasmin. (2001) Increased expression of utrophin in a slow vs a fast skeletal muscle involves post-transcriptional events acting via the 3' UTR. Am J Physiol (Cell Physiol) 281, C1300-C13009.

S. Newey, A.O. Gramolini, J. Wu, R. Nawrotski, D.J. Blake, B.J. Jasmin, and K.E. Davies (2000) A novel mechanism for modulating synaptic gene expression: Differential localization of a-dystrobrevin transcripts in skeletal muscle. Mol Cell Neurosci 17, 127-140.

A.O. Gramolini, J. Wu, and B.J. Jasmin. (2000) Regulation and functional significance of utrophin expression at the mammalian neuromuscular junction. Microsc Res Tech 49, 90-100.

A.O. Gramolini and B.J. Jasmin. (1999) Expression of the utrophin gene during myogenic differentiation. Nucl Acid Res 27, 3603-3609.

A.O. Gramolini, L.A. Angus, L. Schaeffer, E.A. Burton, J.M. Tinsley, K.E. Davies, J.P. Changeux, and B.J. Jasmin. (1999) Induction of utrophin gene expression by heregulin in skeletal muscle cells: Role of the N-box motif and GABP. Proc Natl Acad Sci (USA) 96, 3223-3227.

A.O. Gramolini, G. Karpati, and B.J. Jasmin. (1999) Discordant expression of utrophin and its transcript in human and mouse skeletal muscle. J Neuropath Exp Neurol 58, 235-244.

A.O. Gramolini and B.J. Jasmin. (1998) Molecular mechanisms and putative signaling events controlling utrophin expression in mammalian skeletal muscle fibers. Neuromusc Disord 8, 351-361.

B.J.Jasmin, A.O. Gramolini, F. Adatia, C. Boudreau-Lariviere, R.Y.Y. Chan, A.M. Krupa, J. A. Lunde, and F.A. Mankal. (1998) Nerve-derived trophic factors and transcriptional regulatory mechanisms at the neuromuscular junction of skeletal muscle. Can J Appl Physiol 23, 366-376.

A.O. Gramolini, E.A. Burton, J.T. Tinsley, M.F. Ferns, A. Cartaud, J. Cartaud, K.E. Davies, J.L. Lunde and B.J. Jasmin. (1998) Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism. J Biol Chem 273, 736-743.

A.O. Gramolini and B.J. Jasmin (1997) Duchenne muscular dystrophy and the neuromuscular junction: The utrophin link. BioEssays 19,747-750.

A.O. Gramolini, C.L. Dennis, J.M. Tinsley, G.S. Robertson, J.Cartaud, K.E. Davies and B.J. Jasmin (1997) Local transcriptional control of utrophin expression at the neuromuscular synapse. J Biol Chem 272, 8117-8120.

A. Gramolini and J-M. Renaud (1997) Blocking K+(ATP) channels during metabolic inhibition impairs skeletal muscle contractility. Am J Physiol (Cell Physiol) 272, C1936-1946.

J-M. Renaud, A. Gramolini, P. Light, and A. Comtois (1996) Modulation of muscle contractility during fatigue and recovery by ATP-sensitive potassium channels. Acta Physiol Scand 156, 203-212.