Select Publications

U Kuzmanov, H Guo, J Cosme, R Isserlin, P Sharma, A.O Gramolini*, A Emili*. (2016). Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci (USA)113(44):12592-12597

Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, Robbins CS. (2016). Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth. Nature Immunology.17(2): 159-68.

Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Julius O, Nyalwidhe N, Gramolini AO, Lance RS,Troyer DA, Drake RR, Boutros PC, Semmes OJ and Kislinger T. (2016). Targeted proteomics identifies liquid biopsy signatures for extracapsular prostate cancer. Nature Communications.7: 11906.

Gramolini A, Lau E, Liu PP.(2016). Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases. Circulation. 116: 116.022940.

Sharma P, Abbasi C, Bousette N, Lazic S, Dubois N, Ignatchenko A, Ignatchenko V, Teng A, Wilson A, Noronha M, Wong V, Liu J, Araki T, Liu J, Tiburcy M, Zimmerman WH, Ackerley C, Hamilton R, Sun Y, Liu P, Backx P, Keller G, Stagljar I, Scott I, Kislinger T, Gramolini AO. Tmem65 is an Evolutionary Conserved Membrane Protein that Regulates Cardiac GAP Junction communication.  Nature Communications. 2015; 10.1038/NCOMMS9391.

 Teng A, Miyake T, Yokoe S, Zhang, L, Rezende ML, Maclennan DH, Liu PP, Gramolini AO. Metformin Increases Degradation of Ubiquitinylated Phospholamban via Autophagy in Cardiomyocytes. Proc Natl Acad Sci (USA). 2015;112:7165-7170.

Isserlin R, Merico D, Wang D, Bousette N, Gramolini AO, Bader G, Emili A. Systems analysis reveals down-regulation of a network of pro-survival miRNAs drives the apoptotic response in dilated cardiomyopathy. Molecular BioSystems. 2015;11:239-251.

Wang D, Abbasi C, El-Rass S, Li J, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH,  Cox B, Wen XY, Liu P, Gramolini AO. ERp44 deficiency in mice and zebrafish leads to cardiac developmental and functional defects. Journal of American Heart Association. 2014;3:e001018.

Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nature Communications. 2014;5:3430.

Sun M, Ouzounian M, de Couto G, Chen M, Yan R, Fukuoka M, Li G, Moon M, Liu Y, Gramolini A, Wells GJ, Liu PP. Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways. J Am Heart Assoc. 2013 Apr 22;2(2):e000191. doi: 10.1161/JAHA.113.000191

P. Sharma, U.Nair, W. Li, A. Dong, T. Miyake, A. Wilson, T.Ryan, T. Kislinger, S.Dhe-Paganon, and A.O.Gramolini (2012) Structural Determination of the Phosphorylation Domain of the Ryanodine Receptor.  Febs J 279, 3952-3964.

P.J. Rugg-Gunn, B.J. Cox, F. Lanner, P. Sharma, V. Ignatchenko, A.C. McDonald, J. Garner, A.O. Gramolini, J. Rossant, T. Kislinger (2012) Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells. Developmental Cell 22, 887-901.

N. DuBois, A. Craft, P. Sharma, A. Elephanty, E. Stanley, D. Elliott, A. Gramolini, and G. Keller (2011) Novel use for SIRPA as a specific cell surface marker for the isolation of human pluripotent stem cell-derived cardiomyocytes. Nature Biotechnology 29, 1011-1018.