For this example I generated genotype data at 11 equally spaced markers for 200 ASPs plus their parents using ALLEGRO. The markers were at 0,10,...,90,100cM. Each marker had 4 equally-frequent alleles. For the first 100 families, there was a disease gene at 35cM. The penetrances for this gene were (.05,.9,.9), with a disease allele frequency of 0.015. For the next 100 families, there was a disease gene at 65cM. The penetrances for this gene were also (.05,.9,.9), with a disease allele frequency of 0.015. I then combined data for all 200 families in the file peds.txt. I then: 1) Ran Genehunter using ch.g as the input file, i.e. gh.sun geeout **************************************** References ***************************************** Allegro: Gudbjartsson DF, Jonasson K, Frigge M, Kong A (2000) Allegro, a new computer program for multipoint linkage analysis. Nature Genetics 25: 12-13. Genehunter: Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: A unified multipoint approach. The American Journal of Human Genetics 58: 1347-1363. GEE2loc: Biernacka JM, Sun L, Bull S.B. (2004) Simultaneous localization of two linked disease susceptibility genes. Genet Epidemiol. Published Online Oct 12 2004. In press.