Adrenocortical Carcinoma
Epidemiology and Etiology:
Common sites:
Gross features:
Histologic features:
Immunophenotype:
Marker: |
Sensitivity: |
Specificity: |
Alpha-Inhibin |
|
Not
specific |
MART-1 (melan-A) |
|
Not specific,
also seen in benign adrenal |
Steroidogenic
factor 1 (SF-1) |
|
More
specific? |
Chromogranin
(neg) |
|
Most reliable for
distinguishing from adrenal medullary tumours |
synaptophysin |
|
|
CK (weak or
neg) |
||
Vimentin |
Not specific |
|
EMA (neg) |
||
CEA (neg) |
||
MIB-1 (5-20%) |
||
Beta-catenin |
~30%,
correlates strongly with CTTNB1 mutation |
Not specific CTTNB1 mutation
also present in adenomas (but ?more focal staining in adenoma) |
Molecular features:
Other features:
References: