Adrenal
Hyperplasia
Epidemiology and Etiology:
- Usually secondary
to increased ACTH
- Diffuse hyperplasia
(60-70% of endogenous Cushing syndrome)
Common sites:
Gross features:
- Diffuse
hyperplasia:
- both glands
enlarged (up to 25-40g)
- cortex diffusely
thickened and yellow
- some degree of
nodularity may be seen
- Nodular hyperplasia:
- Bilateral,
0.5-2.0cm yellow nodules scattered throughout the cortex
- Intervening areas
of widened cortex
- Glands combined
30-50g
Histologic features:
- combination
of lipid-laden clear cells and lipid poor compact cells
- some variability in
cell and nuclear size
- occasional binucleate
forms
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
Molecular features:
Other features:
References:
- Robbins &
Cotran Pathologic Basis of Disease (2005)