Normal Adrenal
Epidemiology and Etiology:
Common sites:
Gross features:
- 4g
- lower with acute
stress (lipid depletion)
- higher with
prolonged stress (hypertrophy and hyperplasia
Histologic features:
- zona
glomerulosa (subcapsular)
- zona fasciculata
(75% of cortex)
- zona reticularis
(abutting the medulla)
- medulla
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- hormones:
- mineralocorticoids
(aldosterone mostly)
- glucocorticoids
(cortisol mostly)
- zona fasciculata, some zona reticularis
- sex steroids
(estrogens and androgens)
- catecholamines
(epinephrine mostly)
- chromaffin
cells of medulla
References:
- Robbins &
Cotran Pathologic Basis of Disease (2005)