Nephrogenic Metaplasia / Adenoma
Epidemiology:
Common sites:
- bladder
- prostatic urethra
Gross features:
- <1cm usually
- may be sizeable
Histologic features:
- cuboidal epithelium
- hobnail
appearance
- clear or eosinophilic cytoplasm
- small discrete
nuclei
- papillary growth
pattern often
- tubular
proliferation in underlying lamina propria and
superficial detrusor muscle
- thickened, hyalinized basement membrane surrounding tubules
often
- no stromal response
- variable acute and
chronic inflammation
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
CK7
|
|
|
CK20
|
|
|
PSA / PSAP (neg)
|
|
|
Molecular features:
Other features:
- response of the urothelium to injury
- may mimic adenocarcinoma grossly and microscopically
References: