B12 Deficiency
Epidemiology:
Common sites:
Gross features:
Histologic features:
- swelling of myelin
layers
- degeneration of
axons
- begins segmentally at midthoracic spinal
cord
- with time,
degeneration of axons in both ascending tracts of posterior columns and
descending pyramidal tracts (characteristic)
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- ataxia
- numbness, tingling
in lower extremities
- spastic weakness
of lower extremities
- complete
paraplegia
References: