Mucinous (Colloid)
Carcinoma
Epidemiology:
- 1-6% of breast CA
- older women
Common sites:
Gross features:
- circumscribed mass
- extremely soft
- consistency and
appearance of pale gray-blue gelatin
Histologic features:
- clusters and small
islands of cells within large lakes of mucin
that push into the adjacent stroma
- low-grade features
(required)
- well-circumscribed
borders
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
ER, PR
|
majority
|
|
Molecular features:
- diploid
- hypermethylation of BRCA1 promoter (55%)
- familial:
- slightly higher
incidence in BRCA1 carriers
Other features:
- slightly better
prognosis than NST
- grows slowly over
many years