Flat Epithelial Atypia (FEA)

 

Epidemiology:

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Common sites:

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Gross features:

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Histologic features:

    • columnar cell change
    • nuclear atypia
      • prominent nucleoli
      • rounded nuclei (rather than oval)
      • loss of polarity
    • no complex architecture like rigid bridges or arches or micropapillae

 

Immunophenotype:

Marker:

Sensitivity:

Specificity:

 

 

 

 

Molecular features:

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Other features:

    • May be a precursor to ADH
    • Associated with other neoplastic lesions
      • Commonly accompanies tubular carcinoma

 

References:

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