Apocrine Metaplasia

Epidemiology:

Common sites:

Gross features:

Histologic features:

• various architectural patterns:
• cystic, papillary,
• abundant pink finely granular cytoplasm
• apical tufts or blebs at luminal surface
• round, regular nucleus at the base of the cell
• punctate nucleolus
• almost never mitosis in ordinary apocrine metaplasia

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

• any benign proliferative lesion may contain apocrine metaplasia
• relationship with breast carcinoma is uncertain
• apocrine metaplasia may be seen next to apocrine carcinoma