Phyllodes
tumour
Epidemiology:
Common sites:
Gross features:
Histologic features:
- “leaflike”
architecture
- nodules of
proliferating stroma covered by epithelium
- main feature to
differentiated from fibroadenoma
- benign vs borderline
vs malignant:
- infiltrative
borders
- relatively
well-defined in benign
- stroma outgrows
the epithelial component and infiltrates into the adjacent parenchyma
in malignant
- cellular
- mitoses
- <5/10HPF in
benign
- >5/10HPF in
borderline
- >10/10HPF in
malignant
- nuclear
pleomorphism
- mild in benign
- mild to moderate
in borderline
- severe in
malignant
- may see
heterologous sarcomatous elements in malignant:
- liposarcoma
- chondrosarcoma
- osteosarcoma
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- majority are benign
in behaviour
- high risk of local
recurrence