Collagenous Spherulosis

Epidemiology:

• Incidental finding usually
• frequently associated with sclerosing lesions:
• radial sclerosing lesions
• sclerosed papillomas
• adenosis

Common sites:

Gross features:

• Microcalcifications maybe
• Not a mass lesion usually

Histologic features:

• rounded, acellular, eosinophilic, fibrillary or hyaline, amorphous material surrounded by lobular acini and small ducts
• inner myoepithelial layer
• outer epithelial layer
• lobulocentric pattern
• frequently associated with sclerosing lesions:
• radial sclerosing lesions
• sclerosed papillomas
• adenosis

Immunophenotype:

Marker:	Sensitivity:	Specificity:
Collagen IV
PAS
Alcian blue

Molecular features:

Other features:

References:

· Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, Wick MR. Silverberg's Principles and Practice of Surgical Pathology and Cytopathology: 2-Volume Set. 4th ed. Churchill Livingstone; 2005.