Aging-related chromosomal changes

Epidemiology and Etiology:

· Trisomy 15 is an uncommon finding in BM

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Common sites:

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Gross features:

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Histologic features:

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Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

· Loss of Y

· Note that loss of Y in more than 75% of cells may indicate a clonal population reflective of hematologic disease

· Trisomy 15

· Controversial; conflicting reports

· A recent review suggests that it is an aging-related phenomenon, not associated with any particular hematologic disease (Hanson et al, 2008)

· Previous reports have associated with various hematologic disorders

· MDS mostly

· Chronic myeloproliferative disorders

· AML

· CLL

· CEL

· Nonhematopoietic tumours (ex. hemangiopericytoma)

· Significance of presence in all or most cells may be less certain - ?similar to significance of loss of Y

Other features:

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References:

· Hanson CA, Steensma DP, Hodnefield JM, et al. Isolated trisomy 15: a clonal chromosome abnormality in bone marrow with doubtful hematologic significance. Am. J. Clin. Pathol. 2008;129(3):478-485.