High-Grade Lymphoma Testing Guidelines

· CCO Consensus Pathology Recommendations for Complex Malignant Hematology, Dec. 2016)

· Tests to Perform (required):

· BCL2 (Bcl-2), BCL6 (Bcl-6), MYC (c-Myc), Epstein Barr Virus (EBV)

· Requires immunohistochemical (IHC) / in situ hybridization (ISH) analysis and molecular / cytogenetics testing

· Specific molecular testing may be required for certain entities within the WHO 2016 classification, but these are for sub-classification of the disease and not required for all high-grade lymphoma cases

· HLA typing (where appropriate)

· TATs:

· BCL2, BCL6, MYC, EBV:

· IHC – 24 hours

· DNA rearrangement – 5 days

· Other markers: 14 days

·

References:

· CCO Dec. 2016 Consensus Pathology Recommendations for Complex Malignant Hematology