Pericentric inv(9)

Epidemiology and Etiology:

• Normal variant
• Risk of unbalanced meiosis (as with any inversion)
• Duplication-deficiency chromosome
• One arm distal to breakpoint is duplicated
• The other arm distal to breakpoint is deleted
• The larger the inversion, the greater the chance of duplication-deficiency chromosome being produced
• The larger the inversion, the greater the chance the offspring will survive (smaller regions deleted and duplicated)

Common sites:

Gross features:

Histologic features:

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

References:

• Gersen SL, Keagle MB, eds. Principles of Clinical Cytogenetics (2005).