Pericentric Inversion Y

Epidemiology and Etiology:

· inv(Y)(p11q13) is not uncommon in the general population (normal variant)

Common sites:

·

Gross features:

·

Histologic features:

·

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

·

Other features:

· inv(Y)(p11q13) has no phenotypic effect (normal variant)

· no risk of having an abnormal child

· all sons of the inv(Y) carrier are themselves inv(Y) carriers and all normal

· all daughters are 46,XX

References:

· Gardner RJM, Sutherland GR. Chromosome abnormalities and genetic counseling. Oxford University Press; 2004.