Adenocarcinoma In Situ (AIS)
Epidemiology:
Common sites:
Gross features:
Histologic features:
- glands of adenocarcinoma with the absence of invasion
- atypical columnar
epithelial cells:
- frequent mitoses
(essential)
- apoptotic bodies subadjacent
to the nucleus (same significance as mitoses?)
- elongated,
cigar-shaped, hyperchromatic nuclei
- coarse granular
chromatin
- greatly reduced
amount of cytoplasm with only minimal intracellular mucin
- crowding and pseudostratification with 2 or more rows
- loss of polarity
- architecture of
glands:
- lobular
architecture is common
- numerous outpouchings
- complex
papillary infoldings
- may display cribriform pattern focally
- absence of desmoplastic stromal
reaction
- may have
intestinal or endometrioid type
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
|
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CEA
|
67%
|
|
|
IC5
|
75%
|
|
|
CA-125
|
|
|
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HMFG1
|
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Molecular features:
Other features:
- 30-60% have
concomitant SIL
- 50-90% have
detectable HPV in AIS cells