Microglandular Hyperplasia (MGH)

Common sites:

Gross features:

• usually incidental
• may form a polypoid mass

Histologic features:

• small back-to-back glands
• cuboidal or columnar epithelial cells
• prominent subnuclear and/or supranuclear vacuoles (mucin)
• lumens contain neutrophils and mucin
• mixed acute and chronic inflammatory cells in adjacent stroma
• epithelium may have nuclear atypia, but non-uniform/focal, with a spectrum of changes
• may extend above noninvolved surface
• no pseudostratification
• few mitotic figures

Immunophenotype:

Marker:	Sensitivity:	Specificity:
CEA (neg)

Molecular features:

Other features:

• mucinous microglandular adenocarcinoma of the uterus looks like microglandular hyperplasia, and may be mistaken for it