DDx of Red Cell
Agglutinates
- Cold autoimmune
hemolytic anemia
- Paroxysmal cold hemoglobinuria
- Cold agglutinins
without anemia
- Cold agglutinins
arising after viral or Mycoplasma infection
- Malignant lymphomas
associated with monoclonal IgM spikes
(especially Waldenstrom’s macroglobulinemia)
- Plasma cell dyscrasias with monoclonal IgM
paraprotein spikes