DDx of Eosinophilia

• Allergic disorders:
• Allergic rhinitis
• Asthma
• Atopic dermatitis
• Acute urticaria
• Drug reactions
• Parasitic diseases – tissue-invasive helminthiasis:
• Filariasis
• Schistosomiasis
• Strongyloidiasis
• Trichinosis
• Toxocariasis
• Ascariasis
• Hookworm
• Echinococcus
• Cysticercus
• Other infections:
• Coccidiomycosis
• Tuberculosis
• Cat scratch disease
• Convalescent phase of many infections
• Dermatologic diseases:
• Bullous pemphigoid
• Herpes gestationis
• Recurrent granulomatous dermatitis
• Scabies
• Eosinophilic lymphofolliculosis
• Subcutaneous angiolymphoid hyperplasia with eosinophilia (Kimura disease)
• Episodic angioedema and eosinophilia
• Pulmonary diseases
• Transient pulmonary eosinophilic infiltrates (loffler syndrome)
• Hypersensitivity pneumonitis
• Allergic bronchopulmonary aspergillosis
• Tropical eosinophilia
• Pulmonary infiltrates with eosinophilia (PIE syndrome)
• Collagen vascular disorders
• Allergic angitis and granulomatosis (Churg-Strauss syndrome)
• Angitis with hepatitis B antigenemia
• Rheumatoid arthritis (severe)
• Eosinophilic fascitis
• Sjogren syndrome
• Neoplastic diseases
• Solid tumours
• mucin-secreting
• epithelial cell origin
• lymphomas
• T cell type
• Hodgkin disease
• Leukemias
• T cell lymphocytic leukemia
• myelomonocytic leukemia with eosinophilia (M4Eo)
• Histiocytosis X (eosinophilic granuloma)
• Immunodeficiency diseases
• Selective IgA deficiency
• Swiss-type and sex-linked combined immunodeficiency
• Nezelof syndrome
• Wiskott-Aldrich syndrome
• Hyper-IgE syndrome (Job syndrome)
• Graft-versus-host disease
• Uncommon causes
• Eosinophilic gastroenteritis
• Inflammatory bowel disease
• Chronic active hepatitis
• Chronic dialysis
• Acute pancreatitis
• Postirradiation
• Hypopituitarism