DDx Hemosiderosis

· Hereditary hemochromatosis

· Increased intake of iron

· Increased oral intake of iron (ex. Bantu siderosis)

· Iron-dextran injections

· Transfusions

· Long-term hemodialysis

· Aplastic anemia

· Sickle cell disease

· Myelodysplastic syndromes

· Leukemias

· Pyruvate kinase deficiency

· Impaired use of iron

· Congenital atransferrinemia

· Chronic liver disease

· Ineffective erythropoiesis with increased erythroid activity

· Sideroblastic anemia

· Hemolytic anemias

· Beta-thalassemia

· Porphyria cutanea tarda

References:

· Kumar V, Fausto N, Abbas A. Robbins & Cotran Pathologic Basis of Disease, Seventh Edition. 7th ed. Saunders; 2004.