DDx Hypercoagulable State

· Drugs:

· OCP

· Pregnancy

· Cardiac failure

· Neoplasia

· Adenocarcinomas of the pancreas, colon, lung especially (paraneoplastic syndrome)

· Migratory thrombophlebitis (Trousseau sign)

· Obesity

· Post-operative state

· Prolonged bed rest / immobilization

· Genetic hypercoagulability syndromes

· Factor V mutation (Factor V Leiden)*

· Prothrombin mutation*

· Methyltetrahydrofolate mutation

· hyperhomocysteinemia

· Antithrombin III deficiency

· Protein C deficiency

· Protein S deficiency

· Fibrinolysis defects

· Infections of the abdominal cavity (peritonitis, acute appendicitis, etc) (portal vein thrombosis)

· Acquired hyperhomocysteinemia

* most common

References:

· Kumar V, Fausto N, Abbas A. Robbins & Cotran Pathologic Basis of Disease, Seventh Edition. 7th ed. Saunders; 2004.