DDx of Intraepidermal Vesicular and Pustular Dermatitis

• Intracorneal and subcorneal vesicles and pustules:
• Impetigo
• Staphylococcal scalded-skin syndrome
• Superficial fungal infection
• Pemphigus foliaceus
• Pemphigus erythematosus
• Subcorneal pustular dermatosis
• Infantile acropustulosis
• Erythema toxicum
• Transient neonatal pustular melanosis
• Miliaria crystalline
• Intraepidermal vesicle and pustules:
• Spongiotic vesicles
• Viral vesicles
• Palmoplantar pustulosis
• Friction blister
• Epidermolysis bullosa
• Intraepidermal acantholytic blisters
• Darier disease (keratosis follicularis)
• Grover disease (transient acantholytic dermatosis
• Hailey-Hailey disease (benign familial pemphigus)
• Herpesvirus infection
• Paraneoplastic pemphigus
• Pemphigus vegetans
• Pemphigus vulgaris
• Suprabasilar, intrabasilar:
• Pemphigus vulgaris
• Others?

References:

• Barnhill 2004
• Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, Wick MR. Silverberg's Principles and Practice of Surgical Pathology and Cytopathology: 2-Volume Set. 4th ed. Churchill Livingstone; 2005.