DDx Neonatal Cholestasis

· Idiopathic neonatal hepatitis (30-35%)

· Extrahepatic biliary atresia (25-30%)

· Alpha-1-antitrypsin deficiency (7-10%)

· Intrahepatic cholestasis syndrome (5-6%)

· Alagille’s

· Byler’s

· Others

· Bacterial sepsis (2%)

· Hepatitis

· CMV (3-5%)

· Rubella

· Herpes

· Endocrine

· Hypothyroidism

· Panhypopituitarism

· Galactosemia

· Inborn errors of bile acid biosynthesis (2-5%)

References:

· Russo P, Ruchelli ED, Piccoli DA. Pathology of Pediatric Gastrointestinal and Liver Disease. 1st ed. Springer; 2004.