Fuch’s Endothelial Dystrophy
Epidemiology
and Etiology:
- Primary
loss of endothelial cells
- Symptoms
first start in late middle age
Common
sites:
Gross
features:
Histologic
features:
- Drop-like
deposits of abnormal basement membrane material on Descemet’s
membrane
- Decrease
in endothelial cells
- Stroma thickened and edematous
- Vascularization eventually
- Edema of
basal epithelium
- Bullae between epithelium and
Bowman’s layer
- Fibrous
tissue deposition between epithelium and Bowman’s layer
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular
features:
Other
features:
References: