Gallbladder Adenocarcinoma

Epidemiology and Etiology:

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Common sites:

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Gross features:

· Configurations:

· Exophytic (fungating / polypoid)

· Endophytic (ulcerating)

· Diffusely infiltrating

Histologic features:

· Many contain neuroendocrine cells – should not be considered neuroendocrine carcinomas

· Grading (same as rest of GI tract):

· Grade 1 – well differentiated - > 95% glands

· Grade 2 – moderately differentiated – 50-95% glands

· Grade 3 – poorly differentiated - < 50% glands

· Papillary adenocarcinoma:

· Favorable prognosis

· Intestinal type:

· Gastric foveolar type:

· Mucinous adenocarcinoma:

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Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

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Other features:

· Papillary adenocarcinoma has a favorable prognosis

References:

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