Hamartomatous Polyp
Common sites:
Gross features:
- Juvenile polyps –
large (1-3cm), stalks up to 2cm
- Retention polyps –
smaller (<1cm)
- Peutz-Jeghers polyps – large and pedunculated with a firm lobulated
contour
Histologic features:
- Juvenile and
Retention:
- Expanded lamina propria comprises most of the polyp
- Abundant cystically dilated glands
- Prominent
inflammation common
- Surface may be
congested or ulcerated
- Peutz-Jeghers:
- Arborizing network of connective tissue and
well-developed smooth muscle in lamina propria
- Surrounding
normal abundant glands
- Epithelium rich
in goblet cells
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- Peutz-Jehger Syndrome
- Risk of many malignancies: