Infectious Esophagitis

Common sites:

Gross features:

• candidiasis – patches of adherent, grey-white pseudomembranes
• HSV – punched-out ulcers
• CMV – linear ulceration

Histologic features:

• acute inflammation
• superficial necrosis
• ulceration
• fibrosis with chronicity
• candidiasis – pseudomembranes of fungal hyphae
• HSV – nuclear inclusions in the narrow rim of degenerating epithelial cells at the margin of the ulcer
• CMV – intranuclear and cytoplasmic inclusions in the capillary endothelium and stromal cells in the base of the ulcer

Immunophenotype:

Marker:	Sensitivity:	Specificity:
Virus-specific antigens (HSV, CMV)

Molecular features:

Other features: