Reactive Gastropathy (Chemical / Drug)
Epidemiology:
Common sites:
Gross features:
Histologic features:
- foveolar
hyperplasia
- serrated / corkscrew appearance of gastric neck
cells
- mucin
depletion (>50%), especially in neck region
- smooth muscle in lamina propria
(nonspecific finding)
- enlarged nuclei
- focal, superficial neutrophils
- little or no plasmacytosis
- eosinophilic
/ homogenous erosions
- non-reactive appearance with little
inflammation
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- etiologies:
- drugs
- NSAIDS
- ASA
- bisphosphonates
- chemicals
- bile reflux
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References: