Whipple Disease

 

Common sites:

    • Small intestine
    • Central nervous system
    • Joints

 

Gross features:

    • Small intestine:
      • “shaggy” mucosa
      • thickened wall (edema)

 

Histologic features:

    • small intestine:
      • lamina propria laden with distended macrophages
      • mucosal edema

 

Immunophenotype:

Marker:

Sensitivity:

Specificity:

PASD positive

 

 

 

Molecular features:

    •  

 

Other features:

    • bacterium Tropheryma whippelii
    • rod-shaped bacterium on EM