Coronary
Artery Disease
Epidemiology:
Common sites:
Gross features:
- 2 or all 3 major
coronary vessels often involved
- general
guidelines:
- 70% obstruction –
symptomatic with exercise
- 90% obstruction –
symptomatic at rest
- note that often
those producing MIs are not significant
lesions prior to an acute change (ex thrombus)
- 60%
have only 50% or less occlusion prior to plaque rupture
Histologic features:
- acute plaque
changes:
- rupture /
fissuring with resulting thrombus formation
- often at
junction of plaque with uninvolved arterial segment
- erosion /
ulceration with resulting thrombus formation
- hemorrhage into atheroma, expanding its volume
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
Molecular features:
Other features:
References: