Calcific Aortic Stenosis
Epidemiology:
- Most common of all
valvular abnormalities
- Congenital bicuspid
valves is a risk factor
- 70s and 80s onset
- 50s and 60s
onset with congenitally bicuspid aortic valve
Common sites:
Gross features:
- heaped up calcific masses on the outflow surface of the cusps
at their bases
- commissural fusion
is not a feature (contrast to rheumatic AS)
- little or no
involvement of mitral valve (contrast to
rheumatic AS)
- concentric left
ventricular hypertrophy
Histologic features:
- calcification
begins in the valvular fibrosa
at the margins of attachment (points of maximal cusp flexion)
- layered
architecture preserved
Immunophenotype:
|
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
|
Molecular features:
Other features:
References: