AML with myelodysplasia-related changes
Epidemiology and Etiology:
- Previous history of MDS is sufficient for
diagnosis (unless therapy-related)
- ABSENCE OF prior history of cytotoxic therapy
for an unrelated disease
Common sites:
Gross features:
Histologic features:
- Multilineage
dysplasia is sufficient for diagnosis (unless therapy-related)
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
- ABSENCE OF recurring cytogenetic abnormality as
described in AML with recurrent genetic abnormalities
- Certain cytogenetic abnormalities are sufficient
for diagnosis (unless therapy-related)
- Complex karyotype (>= 3 unrelated
abnormalities)
- -7/7q-
- -5/5q-
- i(17)(q10)
- unbalanced 17p rearrangements
- -13/13q-
- 11q-
- 12p- or unbalanced 12p rearrangement
- 9p-
- idic(X)(q13)
- t(1;3)(p36.3;q21.1)
- t(2;11)(p21;q23)
- most commonly occurs in therapy-related
disease
- t(3;5)(q25;q34)
- t(3;21)(q26.2;q22.1)
- t(5;7)(q33;q11.2)
- t(5;10)(q33;q21)
- t(5;12)(q33;p12)
- t(5;17)(q33;p13)
- t(11;16)(q23;p13.3)
Other features:
References: