N

HIV

(in a lymph node)

Epidemiology and Etiology:

• .

Common sites:

•  .

Gross features:

•  .

Histologic features:

• early stage:
• florid reactive lymphoid hyperplasia
• absent mantle zones
• follicle lysis of germinal centres
• germinal centres disrupted by hemorrhage
• disrupted FDC network
• increased T cells
• monocytoid B cell hyperplasia expanding sinuses
• epithelioid histiocyte clusters
• increased plasma cells in interfollicular zones
• polykaryocytes (large multinucleated giant cells) in interfollicular zones
• late stage:
• regressively transformed germinal centres
• paracortex – depletion of lymphocytes

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

•  .

Other features:

•  .

References:

•  Essentials of Anatomic Pathology, 2^nd Ed (2006)