Kikuchi-Fujimoto

Histiocytic Necrotizing Lymphadenitis

Epidemiology:

• Higher prevalence in Asia
• Young (<40y usually)
• F:M = 4:1
• Unknown etiology
• Viral
• Autoimmune

Common Sites:

Gross features:

Histologic features:

•  paracortex:
• coagulative necrosis
• abundant karyorrhectic debris
• histiocytes, plasmacytoid monocytes, immunoblasts, small and large lymphocytes within karyorrhectic foci
• abundant T cells
• CD8 > CD4

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

•  clinical features:
• acute tender, cervical lymphadenopathy
• low-grade fever
• excellent prognosis

References:

•  Am J Clin Pathol 2004; 122:141-152.