Kimura Disease
Epidemiology:
Common Sites:
- Head and neck
(subcutaneous tissue)
- major salivary
glands
- regional
lymphadenopathy
Gross Features:
- mass lesion
in subcutaneous tissue
Histologic features:
- lymph node:
- marked follicular
hyperplasia
- some may be
progressively transformed
- well vascularized
- containing
polykaryocytes
- interstitial
fibrosis
- proteinaceous
material deposition
- eosinophils
extensive
- occasional
eosinophilic abscesses
- paracortex:
- hyalinized
vessels often
- sinus and
paracortical sclerosis (variable)
- increased plasma
cells and mast cells
Immunophenotype:
|
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
|
Molecular features:
- clonal TCR delta
gene rearrangement has been described (?rare or common?)
Other features:
References: