Primary Cutaneous Follicle Centre Lymphoma (PCFCL)

Epidemiology and Etiology:

Common sites:

• Head
• Trunk

Gross features:

Histologic features:

• Perivascular
• Periadnexal
• Diffuse
• Sparing of epidermis (almost constant

Immunophenotype:

Marker:	Sensitivity:	Specificity:
BCL2 (neg or faint)	most

Molecular features:

• BCL2 rearrangement:
• Many studies show lack of BCL2 rearrangements
• Other studies find 10-40% of those with a follicular growth pattern
• REL amplification
• Deletions:
• 14q32.33
• (lack of CDKN2A and CDKN2B deletions)

Other features:

• Excellent prognosis
• Leg presentation has a more unfavourable prognosis

References:

• WHO blue book (2008)