Progressive Transformation of Germinal Centres

Epidemiology and Etiology:

• NLPHL association:
• Rarely precedes, accompanies, or succeeds NLPHL
• Even more rarely with classic HL
• More often seen in reactive lymphoid hyperplasia

Common sites:

•  .

Gross features:

•  .

Histologic features:

• reactive follicular hyperplasia in the same node
• follicles:
• large
• indistinct germinal centre/mantle zone borders
• mantle cell lymphocytes infiltrating germinal centres
• residual large germinal centre cells (EMA-) may mimic L&H cells (EMA+ usually)
• no nuclear lobulation usually

Immunophenotype:

Marker:	Sensitivity:	Specificity:
EMA (neg) – large residual germinal centre cells

Molecular features:

•  .

Other features:

References:

•  Essentials of Anatomic Pathology, 2^nd Ed (2006)