-bidi-font-family:"Times New Roman";} @list L9:level2 {mso-bidi-font-family:"Times New Roman";} @list L11:level2 {mso-bidi-font-family:"Times New Roman";} @list L12:level2 {mso-bidi-font-family:"Times New Roman";}

Whipple’s Disease

Epidemiology and Etiology:

• Tropheryma whippelli - bacilli
• Middle-aged adults
• M > F

Common sites:

• small bowel
• abdominal lymph nodes
• peripheral lymph nodes +/-

Gross features:

•  .

Histologic features:

• sinuses distended
• large lipid vacuoles surrounded by vacuolated histiocytes

Immunophenotype:

Marker:	Sensitivity:	Specificity:
PAS		MAI are PAS +
ZN (neg)		MAI are ZN +

Molecular features:

• PCR confirmation
• EM confirmation

Other features:

•  .

References:

•  Essentials of Anatomic Pathology, 2^nd Ed (2006)