Aplastic Anemia

Epidemiology and Etiology:

• Drugs
• Chemotherapeutic agents
• Benzene
• Alcohol
• Arsenic
• Radiation
• Viral infection
• Viral hepatitis
• EBV
• Parvovirus B19
• TB
• Paroxysmal nocturnal hemoglobinuria
• Inherited bone marrow failure syndromes
• Fanconi anemia
• Dyskeratosis congenital
• others

Common sites:

Gross features:

Microscopic features:

• Marked panhypoplasia
• Selective erythroid hypoplasia in Parvovirus B19 infection
• Evidence of infection maybe:
• Granulomas
• Intranuclear inclusions
• LACK OF:
• Significant dyspoiesis
• Increased blasts

Immunophenotype:

Marker:	Sensitivity:	Specificity:
Parvovirus viral capsid proteins

Molecular features:

Other features:

• Bi- or pancytopenia usually

References:

• The Washington Manual of Surgical Pathology, 2^nd ed. (2012)