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ErythroidHyperplasia

Epidemiology and Etiology:

Common sites:

Gross features:

Histologic features:

• Increased erythroid precursors:
• Pronormoblasts
• Large (17-24um)
• N:C ratio 8:1
• Finely reticulated (granular) chromatin
• Prominent nucleoli (1 or more)
• Scanty, pale blue, agranular cytoplasm
• Basophilic normoblasts:
• Intermediate size (10-17um)
• N:C 6:1
• Open but “beady” chromatin without significant clumping
• Nucleoli inconspicuous
• Intensely basophilic cytoplasm (royal blue)
• Slight perinuclear clearing
• Perinuclear hof
• Polychromatophilic normoblasts:
• Smaller (10-15um)
• N:C 4:1
• Clumped chromatin with prominent chromocenters
• Nucleoli not visible
• Abundant blue-gray to pink-gray cytoplasm
• Variation in color in the same cell
• Orthochromic normoblasts:
• Small (8-12um
• N:C 1:2
• Pyknotic or densely hyperchromatic nucleus
• May be eccentric
• Abundant pink-orange cytoplasm with a little basophilia

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

References:

• CAP Color Atlas of Hematology 1998