Follicular Dendritic Cell Tumour / Sarcoma

Epidemiology:

Common sites:

• lymph node
• extranodal

Gross features:

Histologic features:

• partial to complete replacement of node
• fascicles and nests
• oval to spindle cells
• bland vesicular nuclei
• inconspicuous nucleoli
• pale cytoplasm
• indistinct cell borders – syncitial appearance
• few mitoses
• scattered small lymphocytes

Immunophenotype:

Marker:	Sensitivity:	Specificity:
CD21
CD35
CD68	Usually
S-100 (neg)	Usually
Clusterin

Molecular features:

Other features:

References:

• Essentials of AP 2006