Mastocytosis
Epidemiology and Etiology:
Common sites:
Gross features:
Histologic features:
Immunophenotype:
Marker: |
Sensitivity: |
Specificity: |
Toluidene
blue (granules) |
Note: may fail
if cells are degranulated |
|
Giemsa
(granules) |
Note: may fail if
cells are degranulated |
|
Tryptase |
All |
good |
Napthol ASD
chloroacetate esterase |
Not good |
|
CD117 |
Not good |
|
CD68 |
|
Not good |
Chymase |
Some |
|
CD2 (expressed
on neoplastic mast cells but not normal mast cells) |
||
CD25 (expressed
in neoplastic mast cells but not normal mast cells) |
||
MPO (neg) |
||
CD45 |
||
CD33 |
||
CD14 (neg) |
||
CD15 (neg) |
||
CD16 (neg) |
Molecular features:
Other features:
References: