Normal RBCs

Epidemiology and Etiology:

·

Common sites:

·

Gross features:

·

Histologic features:

·

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

· 2 pairs of globin chains

· Normal adult:

· HbA (a₂ß₂)

· HbA2 (a₂δ₂) – small amounts

· Fetal hemoglobin (a₂γ₂) – small amounts

Other features:

· Clinically significant hemoglobinopathies result from mutations involving the ß-globin gene

References:

· Kumar V, Fausto N, Abbas A. Robbins & Cotran Pathologic Basis of Disease, Seventh Edition. 7th ed. Saunders; 2004.