Cytomegalovirus (CMV)

Epidemiology and Etiology:

· Herpesvirus family

· DS DNA

Common sites:

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Gross features:

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Histologic features:

· striking enlargement of infected cells

· cellular and nuclear pleomorphism

· Cowdry A bodies – basophilic nuclear inclusions spanning half the nuclear diameter, set off from rest of nucleus by a clear halo

· Cowdry B bodies – large homogenous basophilic (eosinophilic?) cytoplasmic inclusions

· Involved cells

· Endothelial cells

· Fibroblasts

· Smooth muscle cells

· Parenchymal epithelial cells of glandular organs

· Neurons in brain

· Alveolar macrophages, epithelial, and endothelial cells in lungs

· Tubular epithelial and glomerular endothelial cells in kidneys

· Lymph node:

· florid follicular hyperplasia

· monocytoid B cell hyperplasia expanding sinuses

· CMV inclusions may be identified here

· Immunoblastic proliferation may be present

· May be atypical

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Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

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Other features:

· serology

References:

·  Essentials of Anatomic Pathology, 2^nd Ed (2006)

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