Giant Cell Tumour of Tendon Sheath (GCT)
Epidemiology:
- 20s to 40s (older
than PVNS usually)
Common sites:
- tendon sheaths
along wrist and fingers
- spine
Gross features:
- discrete nodule on
a tendon sheath
- red-brown to
mottled orange-yellow
- like a small
walnut
- cortical erosion of
adjacent bone in 15%
Histologic features:
- polyhedral,
moderate-sized tumour cells resembling synoviocytes
- solid nodular
aggregate
- may be attached to
synovium by a pedicle
- hemosiderin deposits
- foamy macrophages
- multinucleated
giant cells
- zones of sclerosis
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- true neoplasm of synovial lining of joints
- similar to to Pigmented Villonodular Synovitis (PVNS)
- often recurs
locally
References: